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    Home > Active Ingredient News > Digestive System Information > Cancers: The neutrophil/lymphocyte ratio (NLR) is a prognostic indicator of first-line TACE treatment for patients with metaphase hepatocellular carcinoma (HCC).

    Cancers: The neutrophil/lymphocyte ratio (NLR) is a prognostic indicator of first-line TACE treatment for patients with metaphase hepatocellular carcinoma (HCC).

    • Last Update: 2021-06-10
    • Source: Internet
    • Author: User
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    Hepatocellular carcinoma (HCC) is one of the common malignant tumors, and its prognosis is poor.


    Hepatocellular carcinoma (HCC) is one of the common malignant tumors, and its prognosis is poor.


    The study retrospectively included patients with interim HCC who were initially untreated from 2008 to 2017 and received TACE treatment in the first line.


    The study retrospectively included patients with interim HCC who were initially untreated from 2008 to 2017 and received TACE treatment in the first line.



    research summary

    The median follow-up time for the overall population was 31 months (IQR, 16.


    The median follow-up time for the overall population was 31 months (IQR, 16.



    Research and validate the OS of different risk groups in the cohort

    When the predictive model was used to validate the cohort for time-dependent ROC curve analysis, the 3- and 5-year AUC values ​​were 0.


    When the predictive model was used to validate the cohort for time-dependent ROC curve analysis, the 3- and 5-year AUC values ​​were 0.



    3-year and 5-year ROC curve

    In the overall population, the median survival time of patients with a baseline NLR <3 was 34.


    In the overall population, the median survival time of patients with a baseline NLR <3 was 34.



    The effect of NLR ratio of the overall population on OS

    Multivariate Cox regression analysis found that the tumor diameter was greater than 5 cm (OR=2.


    Multivariate Cox regression analysis found that the tumor diameter was greater than 5 cm (OR=2.



    Factors related to PD for 6 months of TACE treatment

    Factors related to PD for 6 months of TACE treatment

    In summary, the neutrophil/lymphocyte ratio (NLR) is a prognostic indicator of first-line TACE treatment for patients with metaphase hepatocellular carcinoma (HCC), and a high NLR indicates poor survival.

    In summary, the neutrophil/lymphocyte ratio (NLR) is a prognostic indicator of first-line TACE treatment for patients with metaphase hepatocellular carcinoma (HCC), and a high NLR indicates poor survival.
    The neutrophil/lymphocyte ratio (NLR) is a prognostic indicator of first-line TACE treatment for patients with metaphase hepatocellular carcinoma (HCC), and a high NLR indicates poor survival.
    The neutrophil/lymphocyte ratio (NLR) is a prognostic indicator of first-line TACE treatment for patients with metaphase hepatocellular carcinoma (HCC), and a high NLR indicates poor survival.

    Original source:

    Original source:

    Chu, HH; Kim, JH; Shim,JH; et al.
    Neutrophil-to-Lymphocyte Ratio as a Biomarker Predicting Overall Survival after Chemoembolization for Intermediate-Stage Hepatocellular Carcinoma.
    Cancers 2021, 13, 2830.
    https://doi.
    org /10.
    3390/cancers13112830.

    Chu, HH; Kim, JH; Shim,JH; et al.
    Neutrophil-to-Lymphocyte Ratio as a Biomarker Predicting Overall Survival after Chemoembolization for Intermediate-Stage Hepatocellular Carcinoma.
    Cancers 2021, 13, 2830.
    https://doi.
    org /10.
    3390/cancers13112830.


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