Cardiovasc Diabetol: Different prognostic effects of cardiovascular disease and lower extremity amputation on the risk of all-cause mortality in long-term type 1 diabetes patients

Background: Despite success in reducing the risk of diabetic complications over the past few decades, type 1 diabetes is still associated with an increased risk of premature death compared with matched individuals in the general populati.

Background: Despite success in reducing the risk of diabetic complications over the past few decades, type 1 diabetes is still associated with an increased risk of premature death compared with matched individuals in the general populati.

Objectives: In the current study, we explored whether there are prognostic differences between a history of CVD and nontraumatic LLA in terms of risk of all-cause mortality in patients with long-term type 1 diabet.

METHODS: We used pooled data from prospective cohorts of SURGENE, GENEDIAB and GENES.

Results: Among 1169 participants (55% male, age 40±13 years, duration of diabetes 23±11 years), 49 (2%), 62 (3%) and 20 (7%) were affected, respective.

Table 1 Baseline participant characteristics by incidence of all-cause mortality during follow-up

Figure 1 Kaplan Meier curve estimates of survival based on baseline history of cardiovascular disease (CVD) and lower extremity amputation (LLA): no cardiovascular disease (green line), cardiovascular disease only (red line), LLA only (blue line), and cardiovascular disease Disease and LLA (black lin.

Figure 1 Kaplan Meier curve estimates of survival based on baseline history of cardiovascular disease (CVD) and lower extremity amputation (LLA): no cardiovascular disease (green line), cardiovascular disease only (red line), LLA only (blue line), and cardiovascular disease Disease and LLA (black lin.

Table 2 Risk of all-cause mortality with history of cardiovascular disease or/and LLA at baseline during follow-up

Conclusions: Cardiovascular disease and LLA caused a similar mortality burden in the type 1 diabetes populati.

Conclusions: Cardiovascular disease and LLA caused a similar mortality burden in the type 1 diabetes populati.

Original source: Camoin M, Velho G, Saulnier PJ, et .
Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabet.
Cardiovasc Diabetol 2022 May 09; 21(1) Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabet.
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