Cardiovasc Diabetol: Effects of Liraglutide and Lifestyle Modification on Sst2 and Galectin-3 in Obese Prediabetic Patients or Type 2 Diabetics After Weight Loss

Background: Cardiac fibrosis is characterized by the accumulation of extracellular matrix (ECM) proteins in the cardiac interstitium and is associated with many cardiac pathophysiological conditions
.

Both experimental and clinical evidence suggest that cardiac fibrotic changes may be reversible

Cardiac fibrosis is characterized by the accumulation of extracellular matrix (ECM) proteins in the cardiac interstitium and has been implicated in many cardiac pathophysiological conditions

 Soluble Sst2, a member of the interleukin 1 (IL-1) receptor family, is secreted into the circulation and acts as a "decoy" receptor for IL-33, inhibiting cardioprotective IL-33/ST2 signaling

Liraglutide is an analog of glucagon-like peptide-1 (GLP-1) used in the treatment of type 2 diabetes

RESULTS: Baseline Sst2 levels in the control and obese groups were similar (p=0.
79), while Gal-3 levels were significantly higher than those in the control group (p<0.
001)
.

Liraglutide treatment reduced plasma Sst2 levels (−9%, β=−14.

Figure 1 Baseline plasma Sst2 and Gal-3 levels
.

Comparison of baseline levels of serum Sst2 (A) and Gal-3 (B) in randomly selected control groups and patients

Figure 1 Baseline plasma Sst2 and Gal-3 levels

Figure 2.
Baseline correlation of serum hs-TnI with plasma Sst2 (A) and Gal-3 (B)

Figure 2.
Baseline correlation of serum hs-TnI with plasma Sst2 (A) and Gal-3 (B)

Figure 3 Effects of intervention on plasma ST2 and Gal-3 levels during OGTT
.

Levels of Sst2 and Gal-3 in OGTT of life>

Figure 3 Effects of intervention on plasma ST2 and Gal-3 levels during OGTT

Liraglutide-induced reductions in Sst2 and hs-TnI suggest that the drug may have a positive effect on (cardiac) fibrosis in obese patients with prediabetes or early T2 DM, whereas liraglutide plasma prior to initiation of treatment Gal-3 levels may predict the drug's response to improved beta cell function

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Effects of liraglutide vs.
life>loss