Cardiovasc Diabetol: Elevated IL-12/23p40 Levels as a Potential Indicator of Heart Rate Variability Dysfunction in Type 2 Diabetes

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in type 2 diabetes
(T2D), accounting for approximately 50% of all deaths .

Cardiovascular functions including heart rate, cardiac contractility, and blood pressure are regulated by an autonomic sympathovagal balance, which in diabetic patients may be skewed by diabetic neuropathy

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in type 2 diabetes

Systemic inflammatory processes appear to contribute to the development of cardiovascular complications, leading to increased morbidity and mortality in type 2 diabetes

The researchers analyzed serum samples from 100 people with type 2 diabetes
.

Heart rate variability, cardiovascular autonomic reflex testing, and cardiac vagal tone testing were performed based on ECG readings

The researchers analyzed serum samples from 100 people with type 2 diabetes

The results showed that increased serum IL-12/IL-23p40 (p<0.

Heart rate variability varied with levels of serum markers of inflammation
.

Left: Normal levels of IL-12 and ICAM-1 are associated with normal heart rate variability

Heart rate variability varied with levels of serum markers of inflammation

In conclusion, this study found a strong correlation between cardiac function and serum markers, especially IL-12/IL-23p40, suggesting that systemic alterations in proinflammatory cytokines, endothelial cell, and lymphatic function affect overall cardiovascular function

Reference: Wegeberg, AM, Okdahl, T.
, Riahi, S.
et al.
Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes.
Cardiovasc Diabetol 21, 5 (2022 ).
https://doi.
org/10.
1186/s12933-021-01437-w https://doi.
org/10.
1186/s12933-021-01437-w leave a message here