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Purpose: The natural history of type 2 diabetes is characterized by different patterns of β-cell function
.
In the early stages of the disease, β-cell function is relatively well preserved, and insulin secretion is increased, which is part of the compensation requirement for higher insulin levels to overcome insulin resistance
Beta cell function is relatively well preserved, and insulin secretion is increased, which is part of the compensation requirement for higher insulin levels to overcome insulin resistance
Results: There was a U-shaped relationship between the level of C peptide and the risk of cardiovascular disease.
The low level decreased (<0.
50nmol/l, HR 1.
30[95%CI 1.
05~1.
60], p=0.
02), and the high level increased (>1.
23nmol/ l, 1.
27[1.
00~1.
63], p=0.
05)
.
C peptide level was negatively correlated with severe hypoglycemia (OR0.
Figure 1 The relationship between baseline c-peptide level and cardiovascular disease risk and blood glucose control follow-up measures.
Restricted cubic spline curve and 95% CI of the relationship between c-peptide level and CVD risk
.
The shaded area represents the frequency of c-peptide levels
Figure 1 The relationship between baseline c-peptide level and cardiovascular disease risk and blood glucose control follow-up measures.
Figure 2 The relationship between baseline c-peptide level and blood glucose control follow-up measurement
Figure 2 The relationship between baseline c-peptide level and blood glucose control follow-up measurementConclusion: Low C-peptide levels in patients with advanced type 2 diabetes are associated with increased cardiovascular risk
.
This association has nothing to do with increased blood glucose variability or severe hypoglycemia
Low C-peptide levels in patients with advanced type 2 diabetes are associated with increased cardiovascular risk
Koska J, Nuyujukian DS, Bahn GD, et al.
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