Cardiovasc diabetol: Relationship between the course of diabetes and mortality in hospitalized patients with acute myocardial infarction

Diabetes is associated with an increased risk of death in hospitalized patients with acute myocardial infarction (AMI); However, no studies investigated the effect of duration of
diabetes on in-hospital mortality in people with AMI.

Recently, a research article was published in Cardiovasc Diabetol, an authoritative journal in the field of cardiometabolic diseases, in which researchers assessed the in-hospital mortality rate
of AMI patients based on the status and duration of diabetes in subjects.

Using the Lombardy regional health management database, the researchers included hospitalized AMI patients over the age of 50 with diabetes between 2010 and 2019 and stratified them according to the duration of the diabetes course: < 5 years, 5-10 years, and > 10 years
.
The primary endpoint of the study was mortality during AMI hospitalization, and the secondary endpoint was 1-year mortality
compared to those without diabetes.
Based on diabetes status and duration of disease and AMI type (STEMI and NSTEMI), logistic and Cox regression analyses were used to estimate the odds ratio (ORs, 95% CI) and hazard ratio (HRs, 95% CI).

The researchers assembled a cohort that included 29,566 people with diabetes and 109247 people without diabetes
.
Adjusted for OR and HR showed that people with diabetes had a significantly higher
risk of in-hospital mortality (OR 1.
50, 95% CI 1.
43 to 1.
58) and one-year mortality (HR 1.
51, 95% CI 1.
46 to 1.
55) compared with non-diabetic patients 。 These risks gradually increased with the duration of diabetes and were highest in patients with diabetes duration of more than 10 years (in-hospital mortality OR 1.
59, 95% CI 1.
50 to 1.
69, HR 1.
59, 1-year mortality 95% CI 1.
53 to 1.
64).

These results were similar
in patients with STEMI and NSTEMI.

Thus, the study shows that in hospitalized AMI patients, the duration of diabetes is parallel to the risk of death, and it emphasizes that the duration of diabetes should be considered an important early prognostic risk factor
for AMI patients.

Original source:

Marta Baviera.
et al.
Diabetes mellitus duration and mortality in patients hospitalized with acute myocardial infarction.
Cardiovasc Diabetol.
2022.
https://cardiab.
biomedcentral.
com/articles/10.
1186/s12933-022-01655-w