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Cardiovasc Diabetol: The relationship between the level of glycosylated hemoglobin A1c and cardiovascular outcomes in the general population, the national HA1c screening may become a trend!

 Last Update: 2021-12-02
 Source: Internet
 Author: User

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Assessment of the general population of heart vascular risk is important for clinical decision-making, although clinical've found a lot of new independent biomarkers, cardiovascular risk assessment but still relies on a set of traditional cardiovascular risk factors (CVRFs), such as age , Gender, blood pressure, blood lipid level, diabetes (DM) and smoking
.

Whether to include new biomarkers in cardiovascular risk assessment is still a topic worthy of debate and research

Assessment of the general population of heart vascular risk is important for clinical decision, cardiac vascular although clinical've found a lot of new independent biomarkers, cardiovascular risk assessment but still relies on a set of traditional cardiovascular risk factors (CVRFs), Such as age, gender, blood pressure, blood lipid level, diabetes (DM) and smoking

Diabetes is considered to be a classic risk factor for cardiovascular disease (CVD)

The researchers analyzed data from six prospective population cohort studies in Europe, including 36,180 participants
.

In subjects without diabetes (N=32496) and diabetes (N=3684), HbA1c and cardiovascular mortality, cardiovascular disease (CVD) morbidity and total mortality were evaluated in combination with classical cardiovascular risk factors (CVRFs) Relevance

The researchers analyzed data from six prospective population cohort studies in Europe, including 36,180 participants

Kaplan-Meier curve shows that with the increase of HbA1c level, the incidence of cardiovascular events is higher

Cubic spline of correlation between HbA1c and event occurrence time

Cubic spline between HbA1c and the time of the event Cubic spline between HbA1c and the time of the event Cubic spline between HbA1c and the time of the event

In study participants without diabetes and elevated HbA1c levels, a correlation with CVD morbidity and overall mortality was also observed
.

The HbA1c cut-off values for cardiovascular mortality, cardiovascular disease incidence, and total mortality are 39.

In study participants without diabetes and elevated HbA1c levels, a correlation with CVD morbidity and overall mortality was also observed

In summary, this study shows that glycosylated hemoglobin is independently associated with cardiovascular mortality, total mortality, and cardiovascular disease in the general European population

References: Sinning, C.
, Makarova, N.
, Völzke, H.
et al.
Association of glycated hemoglobin A _1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium.
Cardiovasc Diabetol 20,223 (2021).
https://doi.
org/10.
1186/s12933-021-01413-4 References: Sinning, C.
, Makarova, N.
, Völzke, H.
et al.
Association of glycated hemoglobin A _1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium.
Cardiovasc Diabetol 20, 223 (2021).
https://doi.
org/10.
1186/s12933-021-01413-4 References:Sinning, C.
, Makarova, N.
, Völzke, H.
et al.
Association of glycated hemoglobin A_1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium.
Cardiovasc Diabetol20, 223 (2021).
https://doi.
org/10.
1186/s12933-021-01413-4 References:Sinning, C.
, Makarova, N.
, Völzke, H.
et al.
Association of glycated hemoglobin A_1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium.
Cardiovasc Diabetol 20, 223 (2021).
https://doi.
org/10.
1186/s12933-021-01413-4 Sinning, C.
, Makarova, N.
, Völzke, H.
et al.
Association of glycated hemoglobin A _1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium.
Cardiovasc Diabetol 20, 223 (2021).
https://doi.
org/10.
1186/s12933-021-01413-4 https ://doi.
org/10.
1186/s12933-021-01413-4 Leave a message here

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