echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Cell Breakthrough: Scientists have found a new fat burning pathway with long-lasting potential

    Cell Breakthrough: Scientists have found a new fat burning pathway with long-lasting potential

    • Last Update: 2021-06-04
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Eating without getting fat is the eternal pursuit of foodies.


    On May 27th, local time, the top journal "Cell" published an international research report led by the Novo Nordisk Fundamental Metabolism Research Center at the University of Copenhagen.


    A unique fat burning path

    A unique fat burning path

    As we all know, brown adipose tissue (BAT) is a fat burning "little expert", which can speed up the body's metabolism and promote the consumption of white fat.


    The excitatory G protein (Gs)-coupled receptor family has been proven to be the main cause of BAT activation, and it plays a regulatory role in the acute and adaptive phases of fat thermogenesis.


    In this new study, the researchers used qPCR arrays to find the Gpr3 receptor, which is most clearly expressed under cold induction, from 44 Gs-coupled receptors in mice.


    GPR3 is the Gs-coupled receptor most induced by cold in BAT

    Surprisingly, Gpr3-mediated BAT thermogenesis does not seem to depend on the β-AR pathway.


    Safer, more fat burning, longer lasting

    Safer, more fat burning, longer lasting

    Of course, the key question is whether this newly discovered pathway has better fat burning effect, higher safety, and better clinical transformation possibilities.


    In further experiments, the researchers induced the overexpression of Gpr3 in mice through genetic engineering and lentivirus, and found that at this time, BAT energy consumption is greater, adipose tissue is significantly reduced, and the blood sugar of mice is better controlled.


    GPR3 activates BAT to fight metabolic diseases

    More importantly, increasing the expression level of GPR3 ​​receptors in brown adipocytes can regulate the metabolic homeostasis in obese mice and help them restore normal metabolic functions.


    Gpr3 shows good BAT regulatory potential in mice, but is this target also applicable to humans? Researchers evaluated the GPR3 ​​gene expression in the clavicle BAT of human volunteers with different body mass index (BMI) and glucose tolerance levels, and found that a higher level of BAT GPR3 ​​was significantly associated with a lower BMI, indicating that the expression of GPR3 ​​in humans is related to the whole body Metabolic health is related.


    GPR3 is an essential activator of human BAT

    Moreover, the BAT activation mediated by GPR3 ​​in the human body is also independent of the β-adrenergic receptor-mediated pathway, and enhancing the expression of GPR3 ​​is sufficient to promote the consumption of white fat.


    The first author of the report, Dr.


    In short, this study reveals a new pathway to activate BAT.


    Reference materials:

    [1]https://#%20

    [2]https://cbmr.


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.