Cell breakthrough: Scientists have found a new fat burning pathway with long-lasting potential...

Eating without getting fat is the eternal pursuit of foodies.

On May 27th, local time, the top journal "Cell" published an international research report led by the Novo Nordisk Fundamental Metabolism Research Center at the University of Copenhagen.

A unique fat burning path

As we all know, brown adipose tissue (BAT) is a fat burning "little expert", which can speed up the body's metabolism and promote the consumption of white fat.

The excitatory G protein (Gs)-coupled receptor family has been proven to be the main cause of BAT activation, and it plays a regulatory role in the acute and adaptive phases of fat thermogenesis.

In this new study, the researchers used qPCR arrays to find the Gpr3 receptor, which is most clearly expressed under cold induction, from 44 Gs-coupled receptors in mice.

GPR3 is the Gs-coupled receptor most induced by cold in BAT

Surprisingly, Gpr3-mediated BAT thermogenesis does not seem to depend on the β-AR pathway.

Safer, more fat burning, longer lasting

Of course, the key question is whether this newly discovered pathway has better fat burning effect, higher safety, and better clinical transformation possibilities.

In further experiments, the researchers induced the overexpression of Gpr3 in mice through genetic engineering and lentivirus, and found that at this time, BAT energy consumption is greater, adipose tissue is significantly reduced, and the blood sugar of mice is better controlled.

GPR3 activates BAT to fight metabolic diseases

More importantly, increasing the expression level of GPR3 ​​receptors in brown adipocytes can regulate the metabolic homeostasis in obese mice and help them restore normal metabolic functions.

Gpr3 shows good BAT regulatory potential in mice, but is this target also applicable to humans? Researchers evaluated the GPR3 ​​gene expression in the clavicle BAT of human volunteers with different body mass index (BMI) and glucose tolerance levels, and found that a higher level of BAT GPR3 ​​was significantly associated with a lower BMI, indicating that the expression of GPR3 ​​in humans is related to the whole body Metabolic health is related.

GPR3 is an essential activator of human BAT

Moreover, the BAT activation mediated by GPR3 ​​in the human body is also independent of the β-adrenergic receptor-mediated pathway, and enhancing the expression of GPR3 ​​is sufficient to promote the consumption of white fat.

The first author of the report, Dr.

In short, this study reveals a new pathway to activate BAT.

Reference materials:

[1]https://#%20

[2]https://cbmr.