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Oral administration is a common way of administration, but it is confusing that there are always some drugs, others eat it effectively, when they take it is not effective and may even be counterproductiveAre drugs also "picking people"?recently, researchers at Princeton University solved the mystery by developing a systematic way to assess the transformation or metabolism of oral drugs in the gut: the different gut flora in the human body led to different reactions to the same drug, a widely effective drug that can become a deadly "poison" after it has been administered by some people's gut floraThe report was published in Cell on June 11The gut is a must-have for oral drugs to work in the human body, living in hundreds of bacteria, encoded genes 100 times the human genome, and this vast diversity and richness suggests that there is a range of undescribed biochemical activities of metabolic intake chemicals, in contrast to previous studies of how an gut microbe metabolizes oral drugs, the new study looks at the entire gut flora and provides a more comprehensive and realistic understanding of the role of the gut microbiome in drug metabolism21 fecal samples collected by researchers from anonymous donorsThe types of bacteria living in each individual were classifiedMiraculously, each donor has its own unique microbiome in his or her gut, and most of these individual communities can grow in laboratory culture systems, the researchers developed a combination of biochemical and analytical chemistry and observed the metabolic response of these cultured microbiomes to 575 FDA-approved drugsOf the 438 effectively analyzed drugs, there were 57 examples of gut bacteria that could alter the efficacy of existing oral drugs, 80 per cent of which had not been previously detectedAt the same time, these drugs span 28 pharmacological categories and differ in chemical structurespecifically, changes to oral medications by intestinal flora include turning the drug into an inactive state, reducing the drug's efficacy, or turning the drug into a toxic form that increases the risk of side effectsIn addition, the researchers found that these microbial-derived metabolic reactions can be reproduced in mouse models, meaning that drugs for different populations could be developed in the futureconcluded, the team concluded: "Our framework identifies the interactions between different new drugs and gut microbiomes between individuals and shows how gut microflora can be used in drug development and personalized medicine." "
the first author of the report, Jaime Lopez of the Princeton Lewis-Sigler Institute for Integrated Genomics, says this is a conflicting case between medicine and ecologyThe bacteria in these microbiomes help each other and influence each other's enzyme spectrum If it wasn't for research in a flora, we would never have seen this "
the future, doctors may be able to design different drugs based on each person's gut flora, and patients will no longer have to worry about the side effects of the drug, drug safety issues or some degree of resolution."