Cell Metab: Defects in the liver-bone axis promote the pathogenesis of hepatic osteodystrophy

The research team of Professor Jiang Qing from Nanjing University School of Medicine cooperated with the team of Professor Xue Bin of Shaw Hospital Affiliated to Nanjing Medical University, the team of Professor Li Chaojun of Nanjing Medical University, and the team of Professor Chen Di of Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences.
progress
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Hepatic Osteodystrophy, also known as hepatic osteodystrophy, is a metabolic skeletal disease with an overall change in bone mineral density in patients with chronic liver injury, mostly caused by viral hepatitis, liver cirrhosis, and fatty liver
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The collaborative team's research shows that there is an axial homeostatic regulation between the classical endocrine organ liver and the non-classical endocrine organ bone.
Once the homeostasis is disrupted, it will lead to the occurrence of hepatic bone disease
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Fig.

This study not only revealed the important regulatory mechanism of the liver-bone axis in the progression of hepatic bone disease, but also provided a theoretical basis for the regulation of the interaction between organs, and provided a potential target for drug treatment of hepatic bone disease

Original source:

Lu K, Shi TS, Shen SY, Shi Y, Gao HL, Wu J, Lu X, Gao X, Ju HX, Wang W, Cao Y, Chen D, Li CJ, Xue B, Jiang Q.