Cell Subs: Stimulating adenosine/A2B receptors can significantly resist aging and increase muscle!

On June 25th researchers from the University of Bonn in Germany and the University of Eastern Finland in Finland published their latest research on improving aging and obesity in Cellsm, which found that adenosine A2B receptors, expressed extensively in skeletal muscle (SKM) and brown fat tissue (BAT), have the potential to fight aging and obesityDOI:researchers in mice SKM and BAT by Gs conjugateD GPCR analysis found that A2B is widely expressed in both tissuesAdenosine is an extracellular signaling molecule that transmits signals through four different adenosine receptors (AdoRs) to regulate the physiological function of the tissue: G1-coupled A1 and A3, Gs-coupled A2A and A2B, and stimulates the production of cAMPThe production of CAMP in Adenosine-induced C2C12 cells is eliminated by blocking A2B by specific a2B antagonic PSB603This indicates that the AdoR is highly correlated with the adenosine signaling pathway in SKMIn order to analyze the role of A2B in SKM, the researchers constructed SKM-specific A2B knockout mice (SKMA2B-KO) and found that compared to control, the muscle mass and strength of A2B knockout mice were significantly reduced, the gene expression associated with SKM regeneration was reduced, the level of lipid peroxides associated with aging increased, the aging marker gene increased significantly, and oxygen consumption decreasedConversely, a Combination of A2B agonists Bay 60-6583 to stimulate A2B in older mice significantly increased their muscle mass and strength, causing a significant correction of the indicators and a return to the level of young miceThis suggests that a lack of A2B promotes aging and leads to a decrease in muscle strength and qualitythe A2B signaling pathway in SKM
the researchers constructed adipose-specific A2B knockout mice (ATA2B-KO) to study the function of A2B in brown fat tissue, and found that compared with the control, BAT activity in newborn mice of ATA2B-KO decreased significantly, the total oxygen consumption decreased significantly by 31%, the aging marker gene reduction gene reduction, oxidative stress and lipid oxidation activity increasedThe activation of A2B significantly increased the absorption of BAT quantitative standards and increased oxygen consumption by about three times, restoring almost all expressions to levels similar to those in young miceThis suggests that A2B deficiency promotes aging and albinomy of brown fat cells, and A2B stimulation relieves the conditionAnd A2B is mainly through the formation of amorphous adenosine signal conduction, in SKM and BAT play a rolethe role of A2B in BAT activation and aging
Because A2B can affect energy consumption (EE) in mice SKM and BAT, researchers tested whether A2B stimulation can offset diet-induced obesity findings, pharmacological A2B stimulation can reduce dietary-induced weight gain by affecting systemic EE, while significantly increasing muscle mass and strength in mice, and A2B stimulation has no adverse effects on heart rate and blood pressureA2B treatment offsets diet-induced obesity finally, the researchers analyzed the role of A2B in human BAT and SKM, and found that A2B expression in human BAT was negatively correlated with age and total fat, and a2B expression in SKM was inversely proportional to aging indicators such as oxygen consumption and oxidation metabolism A2B activation enhances the body's muscle mass, including fiber composition, oxidation metabolism, glucose absorption and utilization, and EE in general, this study provides not only a rational understanding of adenosine receptor interactions and A2B function, but also a potentially valuable way to address issues such as aging and obesity, as well as metabolic diseases References: Adenosine/A2B Signaling Ameliorates The Effects of Aging and Acts Counter Obesity