Cell: Terrible! Virus infection causes human-viral hybrid genes to produce human-viral chimeric proteins!

Scientists from the Icahn School of Medicine at Mount Sinai, the University of Glasgow Virus Research Center, the National Institute of Allergy and Infectious Diseases, led by professors at the University of Glasgow's Viral Research Centre and the Icahn School of Medicine at Mount Sinai, have discovered that human and viral hybrids occur during the virus infection process to produce human virus-related proteins, published in the journal "The main highlights of the study include: many viral families use the mechanism of hybrid gene generation;) humans and viruses encode new genes together;) hybrid genes either make extensions of viral proteins or make new proteins;) Human virus genes and human viral proteins work in the pathogenesisPhoto Credit: Viruses are a major threat to human healthThe life cycle of many highly pathogenic viruses such as influenza A virus and Lassa virus depends on the host because the virus polymerase is the host transcript of the cap for the synthesis of the virus ()The researchers hypothesized that the starting cryptoon in the host transcript could produce a chimeric human virus with coding potentialIn the study, researchers reported on the existence of this gene-genesin mechanismThe researchers found that "non-translated areas" that allow the translation of hosts and viruses, depending on the reading box, were created by genetic overprinting to create end-extension viral proteins or completely new peptidesThe researchers also found that both chimeric proteins are produced in infected cells, which produce cellular reactions and promote toxicity caused by viral infectionsOverall, these studies suggest that a host-dependent mechanism allows the generation of hybrid genes when infected with and many other human, animal, and plant viruses() Reference: :