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Edited by Yimaitong, please do not reprint without authorization
.
Obesity is known to contribute to metabolic diseases such as high blood pressure and diabetes, but it may be superficial to attribute the cause to excess fat alone
.
Fat is not just a vessel for storing energy, it also plays a vital role in immune responses, regulating insulin sensitivity, and maintaining body temperature
.
Recently, a study from the University of Pennsylvania, published in the journal Cell, believes that the negative impact of obesity on health stems not only from excess fat, but also from its decreased "responsiveness to change", that is, decreased plasticity
.
Obesity reduces plasticity, leading to the development of other diseases.
The article points out that adipose tissue has a high degree of plasticity, including: (1) maintaining whole-body energy levels when nutrient supply and demand change; (2) adapting to long-term energy balance by expanding and contracting trend; (3) undergo significant structural and metabolic changes during cold exposure, participate in thermogenesis, and more
.
But the composition and function of adipose tissue changes with weight fluctuations and aging
.
Due to aging and obesity, fat becomes less plastic and loses its ability to respond to changes in the body
.
In the current model, the rapid growth of adipose tissue creates a deficit in blood supply, which deprives fat cells of oxygen and results in the accumulation of fat cells that are no longer dividing
.
This leads to insulin resistance, inflammation, and cell death, along with uncontrolled lipid spillover from these cells
.
Figure 1.
Adipose tissue is highly plastic.
New prospects for the treatment of human diseases—identifying and modulating the adipose tissue phenotype.
The central role of adipose tissue dysfunction in disease, and the incredible plasticity of adipose tissue, supports the modulation of adipose tissue phenotype for therapeutic purposes.
purpose possible
.
New insights into the identification and regulation of adipocyte progenitor cells (APCs), adipocytes, immune cells, and other diverse cell types in adipose tissue are expected to reveal novel drug targets that promote metabolically beneficial tissue remodeling
.
SUMMARY This study shows that the negative health effects of obesity stem not only from excess fat, but also from reduced plasticity
.
Yimaitong compiled and compiled from: Sakers A, Siqueira MKD, Seale P, et al.
Adipose-tissueplasticity in health anddisease[J].
Cell,2022;185(3):419.
.
Obesity is known to contribute to metabolic diseases such as high blood pressure and diabetes, but it may be superficial to attribute the cause to excess fat alone
.
Fat is not just a vessel for storing energy, it also plays a vital role in immune responses, regulating insulin sensitivity, and maintaining body temperature
.
Recently, a study from the University of Pennsylvania, published in the journal Cell, believes that the negative impact of obesity on health stems not only from excess fat, but also from its decreased "responsiveness to change", that is, decreased plasticity
.
Obesity reduces plasticity, leading to the development of other diseases.
The article points out that adipose tissue has a high degree of plasticity, including: (1) maintaining whole-body energy levels when nutrient supply and demand change; (2) adapting to long-term energy balance by expanding and contracting trend; (3) undergo significant structural and metabolic changes during cold exposure, participate in thermogenesis, and more
.
But the composition and function of adipose tissue changes with weight fluctuations and aging
.
Due to aging and obesity, fat becomes less plastic and loses its ability to respond to changes in the body
.
In the current model, the rapid growth of adipose tissue creates a deficit in blood supply, which deprives fat cells of oxygen and results in the accumulation of fat cells that are no longer dividing
.
This leads to insulin resistance, inflammation, and cell death, along with uncontrolled lipid spillover from these cells
.
Figure 1.
Adipose tissue is highly plastic.
New prospects for the treatment of human diseases—identifying and modulating the adipose tissue phenotype.
The central role of adipose tissue dysfunction in disease, and the incredible plasticity of adipose tissue, supports the modulation of adipose tissue phenotype for therapeutic purposes.
purpose possible
.
New insights into the identification and regulation of adipocyte progenitor cells (APCs), adipocytes, immune cells, and other diverse cell types in adipose tissue are expected to reveal novel drug targets that promote metabolically beneficial tissue remodeling
.
SUMMARY This study shows that the negative health effects of obesity stem not only from excess fat, but also from reduced plasticity
.
Yimaitong compiled and compiled from: Sakers A, Siqueira MKD, Seale P, et al.
Adipose-tissueplasticity in health anddisease[J].
Cell,2022;185(3):419.
