Chest: BMI has a causal relationship with pulmonary artery pressure, but is not related to the hemodynamic parameters of pulmonary vascular reconstruction.

!---- The relationship between obesity and the pathogenesis and severity of pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) is not yet clearIs body mass index (BMI) associated with pulmonary arterial pressure (PAP) and/or pulmonary vascular remodeling signs? In a recent study published in the journal Chest, the leading journal of respiratory sciences, researchers constructed two BMI genetic risk scores from GWAS aggregatedata and used them for non-overlapping queues of subjects who examined right cardiopulmonary catheterization (RHC) or echocardiogramThe researchers used a BMI risk score (BMI_hpGRS) with the best polymorphism to assess the shared genetic structure of obesity with other characteristics and to associate it with RHC parameters, including pulmonary vascular remodeling markersMendel randomized analysis used a BMI genetic risk score (BMI_sGRS) of high-confidence genetic variation to assess whether a higher BMI caused a higher PAPIn all subjects, directly measured BMI and BMI_hpGRS were positively correlated with pulmonary artery pressure, but not associated with signs of pulmonary vascular remodelingClassification analysis showed that BMI and BMI_hpGRS were PVH-related, but not PAH-relatedBMI_sGRS's Mendel randomization analysis supports higher BMI as the cause of higher constrictal pulmonary arterial pressure (sPAP)Sensitivity analysis showed that the relationship between sPAP and BMI_sGRS persisted when PAH or PVH individuals were excludedIn the echocardiogram queue, BMI and BMI_hpGRS were positively correlated with the estimated PAP and left heart remodeling markersIt can be seen that BMI is the leading factor in the severity of pulmonary hypertension in patients with PAH and PVH, but only related to the pathogenesis of PVH