Chest: Gastroesophageal reflux poses potential risk to late complications in patients with bronchopulmonary dysplasia

Bronary pulmonary dysplasia (BPD) is the most common respiratory disease in very low birth weight infantsAlthough most BPD symptoms improve, some patients experience late-stage complications even when treated routinelyGastroesophageal reflux (GER) is also common in very premature babies and may be associated with many cardiopulmonary symptomsHowever, it is not clear whether GER will increase the risk of advanced complications in infants with BPDrecently published a study in the journal Chest, the leading journal of the field of respiratory research, in which researchers conducted a multicenter prospective cohort study that included 131 BPD infants (79 cases for boys and 52 for girls)After 18 months of follow-up, the incidence of late-stage complications was assessed and the 24-hour pH multichannel intracavity impedance (pH-MII) and intra-gastric sodium concentrations were analyzed for all infants at 36 weeks after menstruation and the last consultationThe researchers analyzed the prevalence and risk factors for advanced complications in children with BPD through forward logistic regressionThe prevalence of advanced complications in infants with BPD was 63.79%, including respiratory symptoms (49.14%), vomiting (38.79%), retinal lesions in premature infants (ROP, 25.86%), hypoxic ischemic injury (3.45%), rehospitalization (26.72%) and sudden death (0.86%)Respiratory disease is the most common complicationThe prevalence of GER in children with BPD was 42.24%, including acidic GER (18.10%) and duocarite gastroesophageal reflux (DGER, 24.14%)The risk factors for respiratory symptoms were the gestational age of 30 weeks (ratio ratio, OR-3.213; 95% CI is 1.221-8.460, birth weight, 1500g (OR- 2.803; 95% CI is 1.014-7.749), with a total ventilation of 7 days (OR-4.952; 95% CI is 1.508-16.267), acidic GER (OR-4.630; 95% CI is 1.305-16.420) and DGER (OR-5.588; 95% CI is 1.770-17.648)BPD and DGER infants are more likely to develop late-stage complications than acidous GER or reflux-free infantsshows that the prevalence of advanced complications in infants with BPD is highGER, ESPECIALLY DGER, POSES A RISK OF THESE LATE COMPLICATIONS