Chimeric exosomes bring new ideas for tumor immunotherapy

Science and Technology Daily, Beijing, October 21 (Reporter Lu Chengkuan) On the 21st, the reporter learned from the Institute of Process Engineering of the Chinese Academy of Sciences that researchers at the Institute created a chimeric exosome to achieve dual targeting of lymph nodes and tumor tissues.

Exosomes are vesicle-type natural biological particles secreted by cells.

"Most of the existing tumor immunotherapy focuses on improving the function and number of immune cells in the body, but it is usually difficult to overcome the immunosuppressive microenvironment of the solid tumor site, making it difficult for the immune cells infiltrating the tumor to effectively exert their anti-tumor function

To this end, the researchers combined more than ten years of research experience in granule formulation, vaccine delivery and tumor immunity, and proposed a new strategy for lymph node-tumor dual-targeting exosomes for dual-effect synergistic tumor immunotherapy

Wei Wei, a researcher at the Institute of Process Engineering, Chinese Academy of Sciences, said that this achievement belongs to preclinical research, and the actual clinical efficacy still needs to be further verified