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Although cancer is not an infectious disease, 17% of deaths worldwide are caused by cancer
Cancer is responsible for 17% of all deaths worldwide Chemotherapy is the mainstay of cancer treatment.
Major mechanisms of cancer MDR:
These mechanisms play a key role in the development of several MDR-reversing agents: aberrant expression of cell membrane transporters, adaptation of cancer cells to the microenvironment, regulation of hypoxia, DNA repair, damage and reduction of apoptosis, enhancement of EMT processes , the presence of cancer stem cells (CSCs) and aberrant activation of key signaling pathways
These mechanisms play a key role in the development of several MDR-reversing agents: aberrant expression of cell membrane transporters, adaptation of cancer cells to the microenvironment, regulation of hypoxia, DNA repair, damage and reduction of apoptosis, enhancement of EMT processes , the presence of cancer stem cells (CSCs) and aberrant activation of key signaling pathways
Regulatory mechanisms of cancer MDR (regulate cancer MDR through the activity of EGFR, PI3K/Akt, MAPKs, Hedgehog and Nrf2 pathways and their downstream target genes):
Modulation of key signaling pathways that overcome MDR by TCM-derived components (which can increase tumor sensitivity to chemotherapeutics and inhibit cancer MDR):
Modulation of key signaling pathways that overcome MDR by TCM-derived components (which can increase tumor sensitivity to chemotherapeutics and inhibit cancer MDR):
Summary of the effects of different compounds of traditional Chinese medicine on cancer MDR:
Summary of the effects of different compounds of traditional Chinese medicine on cancer MDR:Therefore, MDR remains one of the greatest challenges in current cancer chemotherapy
MDR is still one of the biggest challenges encountered in current cancer chemotherapy.
A new multidrug resistance reversal agent provides more support for traditional Chinese medicine in the treatment of cancer multidrug resistance
Original text: Wei J, Liu Z, He J, Liu Q, Lu Y, He S, Yuan B, Zhang J, Ding Y.
Original text: Wei J, Liu Z, He J, Liu Q, Lu Y, He S, Yuan B, Zhang J, Ding Y.
Traditional Chinese medicine reverses cancer multidrug resistance and its mechanism.
Clin Transl Oncol.
2022 Mar;24(3 ): 471-482.
doi: 10.
1007/s12094-021-02716-4.
Epub 2021 Oct 13.
PMID: 34643878.
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