Circ-Heart Fail: The prognostic value of elevated plasma N-acetylneuraminic acid levels in patients with heart failure

Chronic heart failure (HF) is a complex disease involving multiple pathophysiological mechanisms, including cardiomyocyte apoptosis, inflammation, and altered electrical signals, leading to frequent hospitalizations and deaths in HF patients

Recently, the heart blood vessels authority areas Circ-Heart magazine published a research article on Fail, the researchers first assessed the median follow-up of 2 years in the plasma of patients with HF N- acetylneuraminic acid levels associated with adverse cardiovascular events between the incidence of ’S association

Among the 1699 patients with heart failure, 464 (27%) died of cardiovascular-related deaths or received heart transplants

In addition, in the heart tissue of HF patients, the expression of neuraminidase is up-regulated and accompanied by desialylation

Thus, the study revealed a significant correlation between the increase in plasma N-acetylneuraminic acid levels and the increased risk of poor clinical prognosis in HF patients

Chenze Li,et al.