Circulation: Insufficient dietary fiber intake affects cardiovascular health by affecting intestinal flora metabolism

Hypertension (BP) remains a major, poorly controlled but changeable risk factor for cardiovascular deathIn the key factors of Western lifestyle, the lack of dietary fiber is associated with the prevalence of hypertensionThe effects of the lack of probiotic fiber and the mechanisms associated with elevated blood pressure are not clearRecently, researchers found that a lack of prebiotic dietary fiber led to a shift in the gut flora to hypertensive flora, characterized by high blood pressure and its complications, and demonstrated the effect of G protein conjugate receptors (GPCRs) in the intestinal metabolitesthe researchers used C57BL/6J and sterile C57BL/6J mice and knocked out the GPR41, GPR43, GPR109A and GPR43/GPR109A strains in the mice, respectivelyImplantae a small pump (0.25 mg-kg-1-d-1) containing physiological saline or slow-pressure dose angiotensin II in C57BL/6J miceFeeding mice with a dietary microbiome metabolites or a high dietary fiber diet that lacks dietary fiber, as well as the addition or non-addition of a intestinal flora called short-chain fatty acids (SCFA, produced by fermentation in the large intestine)Check for changes in cardiac histology and function, blood pressure, sodium and potassium excretion, gut microbes, flow cytomyte, catecholamine, and methylationlack of prebiotic fiber made mice susceptible to high blood pressure stimulated by mild hypertension, leading to the reconstruction of the pathological heartThe transfer of hypertension bacteria to sterile mice reproduced hypertension phenotypes lacking probiotic fibers, including heart performanceReintroduction of SCFAs to fiber-depleting mice had a protective effect on the occurrence of hypertension, myocardial hypertrophy and fibrosisThe cardiac protection of SCFAs is mediated by homologous SCFA receptor GPR43/GPR109A and regulates l-3, 4-dihydroxyphenylalanine levels and The abundance of cells regulated by DNA methylationthe harmful effects of the low-fiber Western diet may be the basis for high blood pressure, mediated by SCFA deficiency and GPR43/109A signalsMaintaining a healthy, SCFA-producing microbiome is essential for cardiovascular health