Clin Chem: Saliva AMY1 copy number variation regulates age-related type 2 diabetes risk?

!---- the copy number variation (CNV) in the salivary amylase gene (AMY1) regulates salivaalpha-amylase levels and is associated with post-meal blood glucose traitswhether AMY1-CNV plays a role in age-mediated insulin resistance (IR) changes is uncleartested AMY1-CNV with dual quantitative real-time polymerase chain reactions in two studies, the Puerto Rico Health Study (BPRHS, n- 749) and the Lipid-Lowering Drugs and Dietary Network Study (GOLDN, n-980), and the plasma metabolomics in BPRHSassess the relationship between age and blood sugar characteristics and type 2 diabetes (T2D) based on the high or low number of copies of the AMY1 gene to detect the interaction between AMY1-cnv and ageIn addition, the relationship between metabolites and AMY1-CNV and age interactions on T2D risk was also studiedfound that in two studies, subjects with low AMY1 copies had a positive correlation with agethere was little age correlation between T2D and participants with low number of starch 1 copies in BPRHS but high in starch 1 copymetabolic pathway enrichment analysis found that the glucose metabolic pathway is based on metabolites associated with IR and AMY1-CNV interaction with ageIn addition, in older participants, the number of copies of high starch 1 was often associated with lower levels of rnaycolic acid, red alginate and arabic acid, all of which were positively correlated with IRfindings support the role of AMY1-CNV in changing the relationship between age and IRindividuals with low anumber of AMY1 copies also increase their IR as they age.