Clin Gastroenterology H: Delays in the treatment of Helicobacterrobacteria re-infection increase the risk of bleeding in the upper digestive tract

H.pylori infection is an independent risk factor for peptic ulcers.
studies have shown that 43-56% of patients with peptic ulcer bleeding (PUB) have Helicobacter pyrethrobacteria infection.
a recent study in Sweden showed that delaying the eradication of Helicobacterrobacteria increases the risk of ulcers and results in complications in a time-dependent manner.
study aims to explore the effects of the failure of the initial eradication of Helicobacter pyridobacteria treatment on the risk of subsequent upper digestive bleeding (UGIB) at different times.
researchers conducted a retrospective cohort study of 70,518 patients with Helicobacter pyridosis infection who received triple therapy based on clarithromycin from January 2003 to December 2012.
8,330 patients, or 11.8 percent, needed retreated after the initial treatment failed.
patients were classified according to the initial and final time (3 months or less, 3-12 months, and more than 12 months) to eradicate Helicobacter pyridosis.
the main observational outcome was the difference in UBIBs between patients who needed retreated and those who did not.
compared to the control group, patients who still needed retreated had a higher risk of UBEB (HR 1.50, 95% CI 1.34-1.69) even after the last eradication treatment.
from initial eradication treatment to eventual eradication treatment, the longer the risk of UGIB increases: a risk ratio of less than 3 months is 1.16; .35;95%CI, 1.07-1.69, with a risk ratio of 1.68 for more than 12 months; 95%CI, 1.46-1.94 (P s .038).
who initially failed to eradicate Helicobacterium were at increased risk of developing UGIB compared to patients who initially responded to the study.
the risk increases as the time for retreation increases.
should consider retreated as early as 3 months to minimize the risk of subsequent UBIBs.