Clin Gastroenterology H: Long-term remission in patients with ulcerative colitis is associated with the number of mucous membrane-neutral granulocytes.

The therapeutic goal of ulcerative colitis (UC) has shifted from symptom control to improving mucosa performance under the endoscope.
, although treatments are emerging, only one-third of moderate to severe UC patients still achieve endoscopic remission.
histological remission is becoming a key guiding therapeutic endpoint in UC clinical trials, and this study examines the correlation between the histological characteristics of the colon mucosa in patients with ulcerative colitis (UC) and clinical outcomes during 3 years of follow-up.
researchers collected clinical data on 281 UC patients in a third-level medical unit between 2009 and 2013, including 889 biopsy specimens of the colon segment.
used a validated histological scoring system (Geboes score, Nancy score) to evaluate biopsy tissue pathology indicators, as well as Robarts histological pathology indicators.
same time, the researchers collected clinical, endoscopic and histological data from patients and assessed their relevance to systemic corticosteroid use, hospitalization and colonectomy within three years of colonoscopy.
researchers found histological evidence of disease activity in 65 percent (182) UC patients (Geboes score ≥2B.1) and endoscopic evidence of UC activity in 149 patients.
histological characteristics of UC activity were associated with an increase in systemic corticosteroid use, colonectomy and hospitalization throughout the queue (P-lt;0.05) and an increase in systemic corticosteroid use in endoscopic-only patients (P <.001 p" 0.001.
Patients with only a small amount of mucosal negatose cells had higher levels of systemic corticosteroids than patients without histological evidence of UC activity (">UC patients had small amounts of negatose cells in the colon mucous membrane, which is an independent risk factor for increased risk of systemic corticosteroid hormones."
the complete disappearance of neophil-related inflammation should be the goal of UC treatment.
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