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Clin Trans Gastroenterology: Patients with different subtypes of achalasia have different numbers of interstitial cells in Cajal and are related to prognosis

 Last Update: 2021-09-28
 Source: Internet
 Author: User

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Achalasia is a primary disorder of esophageal motility transport, which is characterized by impaired relaxation of the esophageal sphincter (LES) and abnormal peristalsis during swallowing

The cause of achalasia is not fully understood

According to version 3.

In this study, 122 patients with achalasia who underwent oral endoscopic myotomy and 10 control patients who underwent esophagectomy for esophageal cancer were included in LES muscle specimens

immunity

The results of the study showed that the number of ICCs in type I achalasia patients was significantly lower than that in type II achalasia patients, and the number of ICCs in the control group was significantly higher (type I vs type II vs control group = 0.

Figure: Differences in the number of cells in different types of achalasia patients

This study confirmed that ICC and nNOS positive cells were significantly reduced in the LES muscles of patients with achalasia

Chen, Songfeng.

The Number of Interstitial Cells of Cajal Differs Among Different Subtypes of Achalasia and is Related to Patients' Prognosis.

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