Clinical Nutrition: Nutritional and immunologic dysfunction in patients with early pancreatic cancer with pancreatic hemostomy and its effect on prognostics

Background and goals Even in the early stages of pancreatic cancer, malnutrition is common and has a significant impact on clinical outcomes.
the purpose of this study is to explore the effects of immune and nutritional disorders and prognosis in the waiting group of patients who are planning a pancreatic heliostomy because of suspected pancreatic cancer.
method researchers analyzed patients who under performed a pancreatic heliostomy at Vilnius University Hospital between January 2016 and November 2018.
patients were randomly divided into immunotrophic and control groups, and for tumors, pancreatic catheterized adenocarcinoma (PDAC) and other pancreatic tumors were classified.
nutrition assessments include screening (NRS 2002), anthometic, bioresist resistance analysis, and lumbar skeletal muscle index (LSMI).
to measure inflammation before and after surgery.
the outcome of the operation using the Comprehensive Complications Index (CCI) 30 days after surgery.
, although an increased nutritional risk was found in 22.4% of patients, the proportion of people who were eventually diagnosed with a bad disease was 41.4%.
although obese patients were primarily diagnosed with erythrosis, muscle reduction was found in all BMI categories, while 11.7 per cent of obese patients had muscle reduction.
found a decrease in LSMI in 52.5% of patients.
regression model showed that nutritional indicators had a significant impact on CCI (R2 coefficient was 71.1%).
compared to other patients with pancreatic tumors, PDAC patients were characterized by an increase in inflammation throughout the body before surgery and a decrease in inflammation after surgery (p s 0.02).
findings found high rates of nutritional disorders, including abnormal body composition, in the queue of patients with early pancreatic cancer, which had a negative impact on postoperative outcomes.