Common drugs that are forbidden for patients with broad bean disease, you will understand after reading this article!

Many broad beans and broad bean products have always been favored by people

Many broad beans and broad bean products have always been favored by people

However, a small number of children will experience physical discomfort after eating, such as fatigue, chills, fever, dizziness, headache, vomiting, abdominal pain, etc.

Parents should be vigilant when the above symptoms appear after eating broad beans and broad bean products for the first time! It could be fava bean disease

So what is broad bean disease? How should the disease be prevented ? prevention

What is broad bean disease?

What is broad bean disease? What is broad bean disease?

Broad bean disease, medically known as erythrocyte glucose -6- phosphate dehydrogenase deficiency, referred to as G6PD enzyme deficiency

Broad bean disease, medically known as erythrocyte glucose -6- phosphate dehydrogenase deficiency, referred to as G6PD enzyme deficiency

The G6PD enzyme is an enzyme present on the membrane of human red blood cells, which is involved in the metabolism of glucose by red blood cells, and in the process produces a substance that can protect red blood cells from oxidative threats

Because many cases develop within 48 hours of eating fresh broad beans or broad bean products , G6PD enzyme deficiency is also commonly known as " broad bean disease "

Clinical manifestations of faba disease patients: 

1.

1.

2.

3.

4.

The main causes of broad bean disease are: The main causes of broad bean disease are:

1.

1.

2.

3.
Nursing mothers eat broad beans and their products, and are exposed to broad bean pollen

4.
Taking antipyretic analgesics and some exposure to antimalarial drugs, sulfonamides, etc.
 

4.
Taking antipyretic analgesics and some exposure to antimalarial drugs, sulfonamides, etc.
 

5.
Infectious causes: viral hepatitis, influenza, pneumonia, typhoid, mumps

5.
Infectious causes: viral hepatitis, influenza, pneumonia, typhoid, mumps infection

Status of broad bean disease:

Status of Broad Bean Disease: Status of Broad Bean Disease:

It occurs frequently in the southern regions of China, with the most in Guangdong, Sichuan, Guangxi, Hunan and Jiangxi
.
The disease is more common in children under the age of 5 , and more men than women .
Broad bean disease is a hereditary blood system disease that cannot be cured, but can be prevented .

It occurs frequently in the southern regions of China, with the most in Guangdong, Sichuan, Guangxi, Hunan and Jiangxi
.
The disease is more common in children under the age of 5 , and more men than women .
Broad bean disease is a hereditary blood system disease that cannot be cured, but can be prevented .
child

Why is the disease mainly in children ?

Why is the disease mainly in children ? Why is the disease mainly in children ?

This may be related to indigestion in children , abnormal intestinal permeability, and easy entry of broad bean protein into the human body.
Some studies also believe that with the increase of age, the quality and quantity of enzymes are gradually improved, and the spleen function and various physiological functions are more perfect.
, The body has a certain neutralizing effect on broad bean and some oxidative drugs, so it has a curb effect on the pathogenesis of broad bean disease
.

This may be related to indigestion in children , abnormal intestinal permeability, and easy entry of broad bean protein into the human body.
Some studies also believe that with the increase of age, the quality and quantity of enzymes are gradually improved, and the spleen function and various physiological functions are more perfect.
, The body has a certain neutralizing effect on broad bean and some oxidative drugs, so it has a curb effect on the pathogenesis of broad bean disease
.
Digestion

In addition, it is possible that after the onset of childhood, most children will fast from broad beans later, so the incidence of adolescents and the elderly will be reduced
.

In addition, it is possible that after the onset of childhood, most children will fast from broad beans later, so the incidence of adolescents and the elderly will be reduced
.

Food and drug contraindications for patients with broad bean disease:

Food and drug contraindications for patients with broad bean disease: Food and drug contraindications for patients with broad bean disease:

1.
Food and daily necessities

1.
Food and daily necessities

1.
Broad beans and their products include vermicelli, soy sauce, bean paste,
etc.
It should be noted that fresh broad beans are more oxidative than cooked broad beans, and fresh broad beans are almost 100% hemolyzed
.
In addition, in addition to avoiding eating broad beans, try to avoid going to the broad bean planting fields during the harvest season of broad beans, because broad bean pollen may cause severe hemolysis in patients
.

1.
Broad beans and their products include vermicelli, soy sauce, bean paste,
etc.
It should be noted that fresh broad beans are more oxidative than cooked broad beans, and fresh broad beans are almost 100% hemolyzed
.
In addition, in addition to avoiding eating broad beans, try to avoid going to the broad bean planting fields during the harvest season of broad beans, because broad bean pollen may cause severe hemolysis in patients
.

2.
Mothballs: The naphthalene contained in mothballs can also cause acute hemolysis in patients with broad bean disease, so such things are prohibited in the wardrobes of both adults and children.
Once the clothes come into contact with them, they must be exposed to sunlight before they can be worn by babies
.

2.
Mothballs: The naphthalene contained in mothballs can also cause acute hemolysis in patients with broad bean disease, so such things are prohibited in the wardrobes of both adults and children.
Once the clothes come into contact with them, they must be exposed to sunlight before they can be worn by babies
.

3.
Others: Bita wine (contains bezoar), white flower oil, panacea oil, safflower oil (contains salicylic acid)
.
 

3.
Others: Bita wine (contains bezoar), white flower oil, panacea oil, safflower oil (contains salicylic acid)
.
 

2.
Chinese medicine 

2.
Chinese medicine 

At present, there are clear studies showing that patients with broad bean disease should avoid the use of Chinese medicines such as bezoar, honeysuckle, Sichuan lotus, pearl powder, wax plum blossoms, or Chinese patent medicines containing the above components
.
 

At present, there are clear studies showing that patients with broad bean disease should avoid the use of Chinese medicines such as bezoar, honeysuckle, Sichuan lotus, pearl powder, wax plum blossoms, or Chinese patent medicines containing the above components
.
 

3.
Western medicine

3.
Western medicine

Take the initiative to inform the doctor that you are a patient with broad bean disease and do not self-medicate.
The following are some drugs that patients with broad bean disease should avoid as much as possible
.
 

Take the initiative to inform the doctor that you are a patient with broad bean disease and do not self-medicate.
The following are some drugs that patients with broad bean disease should avoid as much as possible
.
 

1.
Antimicrobial drugs: levofloxacin, moxifloxacin, ciprofloxacin, compound sulfisoxazole, furazolidone, nitrofurazone, chloroquine, primaquine, streptomycin, isoniazid, chloramphenicol,
etc.
 

1.
Antimicrobial drugs: levofloxacin, moxifloxacin, ciprofloxacin, compound sulfisoxazole, furazolidone, nitrofurazone, chloroquine, primaquine, streptomycin, isoniazid, chloramphenicol,
etc.
 

2 , hypoglycemic drugs: such as glyburide, gliclazide, glimepiride, glipizide,
etc.
 

2 , hypoglycemic drugs: such as glyburide, gliclazide, glimepiride, glipizide,
etc.
 

3.
Vitamins: such as vitamin K3 , vitamin K4 , vitamin K1 , vitamin C.

 

3.
Vitamins: such as vitamin K3 , vitamin K4 , vitamin K1 , vitamin C.

 

4.
Antipyretic analgesics: such as acetaminophen, analgin, aspirin, aminopyrine,
etc.

4.
Antipyretic analgesics: such as acetaminophen, analgin, aspirin, aminopyrine,
etc.

5.
Others: hydroxychloroquine, isosorbide nitrate, sulfasalazine, methylene blue, bupivacaine
.
Lower risk drugs such as chlorpheniramine, diphenhydramine, colchicine, dopamine, doxorubicin, matrine, levodopa, phenytoin, trihexyphenidyl,
etc.

5.
Others: hydroxychloroquine, isosorbide nitrate, sulfasalazine, methylene blue, bupivacaine
.
Lower risk drugs such as chlorpheniramine, diphenhydramine, colchicine, dopamine, doxorubicin, matrine, levodopa, phenytoin, trihexyphenidyl,
etc.

Broad bean disease is divided into four categories based on the pathogenic variant :

Broad bean disease is divided into 4 classes based on pathogenic variants: Broad bean disease is divided into 4 classes based on pathogenic variants :

The pathogenic variants in G6PD deficiency are classified into categories I to IV according to the relevant phenotype (the classification of enzyme activity recommended by WHO), and most pathogenic variants in individuals with G6PD deficiency belong to categories I , II , and III .
Very few are category IV , which are classified as follows: 

The pathogenic variants in G6PD deficiency are classified into categories I to IV according to the relevant phenotype (the classification of enzyme activity recommended by WHO), and most pathogenic variants in individuals with G6PD deficiency belong to categories I , II , and III .
Very few are category IV , which are classified as follows: 

Class I pathogenic variants resulting in severe enzymatic deficiency with congenital aspheric hemolytic anemia;

Class I pathogenic variants resulting in severe enzymatic deficiency with congenital aspheric hemolytic anemia;

A class II pathogenic variant results in a severe deficiency of enzymatic activity;

A class II pathogenic variant results in a severe deficiency of enzymatic activity;

Class III pathogenic variants resulting in mild to moderate deficiency of enzymatic activity;

Class III pathogenic variants resulting in mild to moderate deficiency of enzymatic activity;

Class IV pathogenic variants result in mildly reduced or normal enzyme activity
.

Class IV pathogenic variants result in mildly reduced or normal enzyme activity
.

More than 30 G6PD pathogenic variants have been identified in the Chinese population , most of which belong to class II or class III .
Some people may develop the disease while taking the above-mentioned drugs, while others do not.
This may be related to individual characteristics, namely the degree of G6PD deficiency, and to the dose of the drug .


 

More than 30 G6PD pathogenic variants have been identified in the Chinese population , most of which belong to class II or class III .
Some people may develop the disease while taking the above-mentioned drugs, while others do not.
This may be related to individual characteristics, namely the degree of G6PD deficiency, and to the dose of the drug .


 

Acetaminophen, aspirin, levofloxacin, compound sulfisoxazole, vitamin C , glyburide, etc.
were previously considered unsafe, but existing studies have shown that in adults with G6PD deficiency ( WHO classes II and III ) It is probably safe given conventional therapeutic doses
.

Acetaminophen, aspirin, levofloxacin, compound sulfisoxazole, vitamin C , glyburide, etc.
were previously considered unsafe, but existing studies have shown that in adults with G6PD deficiency ( WHO classes II and III ) It is probably safe given conventional therapeutic doses
.

While vitamin K , colchicine, diphenhydramine, doxorubicin, and levodopa were associated with non-hemolytic anemia but not with G6PD deficiency
.
In adults with G6PD deficiency ( WHO classes II and III ) the drug is generally considered safe at the usual doses for treatment
.
 

While vitamin K , colchicine, diphenhydramine, doxorubicin, and levodopa were associated with non-hemolytic anemia but not with G6PD deficiency
.
In adults with G6PD deficiency ( WHO classes II and III ) the drug is generally considered safe at the usual doses for treatment
.
 

Drugs such as nitrofurantoin, nifuratel, nitrofuracil, methylene blue, and primaquine have a high risk of developing fava bean disease, and patients with faba bean disease should strictly avoid their use
.

Drugs such as nitrofurantoin, nifuratel, nitrofuracil, methylene blue, and primaquine have a high risk of developing fava bean disease, and patients with faba bean disease should strictly avoid their use
.


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