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Computationally enabled microorganisms have made progress in building the bottom building blocks of synthetic biology

 Last Update: 2021-06-02
 Source: Internet
 Author: User

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Biochemical reaction networks by the enzyme-driven core foundation of life activities, micro- bioon.

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In the field of biosynthetic pathway design, "biological reverse synthesis" is a design method that has been widely used in recent years.

The team of Wu Bian, a researcher at the Institute of Microbiology, Chinese Academy of Sciences, reported on Nature Catalysis in May 2021 on the research results of large-scale calculation and redesign of protein to construct a platform for microbial unnatural amino acid synthesis on Nature Catalysis.

Based on the previous work, the researchers put forward the design principles for hydroamidase, and under the guidance of the design principles, the hydrogen bond network of the active center of aspartase was segmented, and the approximate reaction state geometrical scale was depicted.

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