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Trauma-induced coagulopathy mainly includes thrombocytopenia and platelet dysfunction that affect the prognosis of patients
.
However, the role of platelet transfusions remains unclear
Recently, a research article was published in Critical Care, an authoritative journal in the field of critical care medicine.
The purpose of this study was to 1) evaluate the effect of early platelet transfusion on 24-hour all-cause mortality; 2) describe the platelet count at admission and its Relationship between trauma severity and patient outcomes
.
In an observational study conducted in a multicenter prospective trauma registry, researchers included all adult trauma patients admitted directly to a trauma center between May 2011 and June 2019
.
Major bleeding was defined as transfusion of more than 4 RBC units within 6 hours and/or death due to blood loss
Among the 19,596 patients included, the platelet count on admission (229 g/L [189-271]) was associated with coagulation disorders, trauma burden, shock, and bleeding severity
.
In a logistic regression model, the researchers found that every 50 g/L decrease in platelet count was associated with a 37% increase in 24-hour all-cause mortality (OR 0.
CONCLUSIONS: Although the platelet count on admission is mainly within the normal range, it is associated with trauma severity and coagulation dysfunction and can predict bleeding intensity and patient outcome
.
Early platelet transfusion within 6 hours is associated with reduced mortality in patients with severe bleeding
Although the platelet count on admission is mainly within the normal range, it correlates with trauma severity and coagulation dysfunction and can predict bleeding intensity and patient outcome
Original source:
SR Hamada.
Impact of platelet transfusion on outcomes in trauma patients Leave a message here
