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Crit Care: The effect of tranexamic acid on thrombotic events and seizures in bleeding patients

 Last Update: 2021-11-12
 Source: Internet
 Author: User

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Tranexamic acid (TXA) can reduce surgical bleeding and reduce deaths caused by trauma and bleeding after delivery
.

However, it is effective for thrombotic events andEpilepsy affect seizures remains unclear

thrombusepilepsy

Recently, a research article was published in Critical Care, an authoritative journal in the field of critical care medicine.
Researchers conducted a systematic review and meta-analysis to evaluate the safety of TXA treatment in patients with bleeding
.

In this systematic review and meta-analysis, the researchers evaluated MEDLINE, EMBASE, and the Cochrane Registry of Randomized Controlled Trials.
The search time was from the establishment of the database to June 1, 2020
.

The researchers included randomized trials comparing the efficacy of intravenous tranexamic acid with placebo or no intervention in patients with bleeding

Stroke

A total of 234 studies and 102,681 patients were included in the meta-analysis
.

In bleeding patients, there is no evidence that TXA increases thrombotic events (RR=1.

Coronary Syndrome

Thus, tranexamic acid does not seem to increase the risk of thrombotic events in bleeding patients
.

However, because the risk of seizures may increase in a dose-dependent manner, very high doses of TXA should be avoided

Tranexamic acid does not seem to increase the risk of thrombotic events in bleeding patients

Original source:

Shuhei Murao.

Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis in this message

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