Dev Cell: Smokers express ACE2 higher and are susceptible to coronavirus infection

Data2020 May 20 News / BioValley BIOON / --- from COVID-19 patients showed that smokers at higher risk of complicationsResearchers at May 15, published in the "DevelopmentalCell" magazine article, said one possible reason is that smoking increases ACE2 (in conjunction with SARS-CoV-2 protein) gene expression, which may promote COVID-19 infectionThe study showed that for a long time that smoking causes lung increase in ACE2 protein may lead to a higher incidence of patientsauthor of the article, Cold Spring Harbor Laboratory Cancer Yizhuanxuejia JasonSheltzer said: "Our findings suggest why the smoking population in the new crown after infection the virus tends to produce poor clinical results we found that smoking causesACE2 expression was significantly increased, while ACE2 is SARS-CoV-2 protein into the human cell used"a (source: Www.pixabay.com)Sheltzer says:" mice from experiment evidence suggests that high levels of ACE2 expression in the mice more susceptible to SARS"the latest study of SARS-CoV-2 found that when human ACE2 is highly expressed in the mouse, the faster the rate of death in mice infected with a new crown after a virus"
lung is one of the main organs of ACE2 expression in order to assess the direct impact of smoking on lung ACE2 expression, Sheltzer compared the expression .Sheltzer smoking regularly and never smokers lung epithelial tissue, said ACE2 gene : "we found that smoking causes a significant increase in ACE2 expression," he said ACE2 smokers of more than 30% -55% higher than non-smokers this change also dose-dependent, namely heavy smokers highest level of ACE2 expressionEffect of ACE2 maysmoking goblet cell lung .Sheltzer about said: "goblet cells produce mucus, in order to protect against the inhalation of respiratory tract irritationThus, the expression of ACE2 to increase the smokers' lung may be caused by smoking secreting cell proliferation byproducts"ACE2 also associated with increased inflammatory pulmonary disease COPD and idiopathic pulmonary fibrosisFurther, Sheltzer results show that the composition of other viral infection (e.ginfluenza) and interferon signaling (human viral defense system section) can increase the expression of .Sheltzer ACE2, said: "As a result, SARS-CoV-2 could trigger raised its own receptor, so as to form a positive feedback loop, leading to more infections "
despite the effects of smoking on ACE2 expression is very significant, but this is not permanent By comparing smokers with lung quit smoking for at least 12 months of human lung, Sheltzer found" ACE2 expression was significantly decreased, suggesting that smoking cessation can reverse the effect of smoking on the promotion of up-regulated expression of ACE2 "(bio Valley Bioon.com) information source: SmokersmorelikelytoexpressACE2proteinthatSARS-COV-2usestoenterhumancells original source: JoanC.Smithetal, CigarettesmokeexposureandinflammatorysignalingincreasetheexpressionoftheSARS-CoV-2receptorACE2intherespiratorytract, DevelopmentalCell (2020) .DOI: 10.1016 / j.devcel.2020.05.012