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Diabetes Care: How far is the road from type 1 diabetes to end-stage renal disease?

 Last Update: 2021-05-08
 Source: Internet
 Author: User

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，1(ESKD)，-(RAS)。，medsci.

Fortunately, ESKD can be prevented or delayed by intensive hypoglycemic and antihypertensive therapy , so early detection is necessary.

There are few prediction models of ESKD for type 1 diabetes, and three prediction models have been established for people with type 2 diabetes.

Based on this, some researchers have established an ESKD risk prediction model that takes into account the competitive risk of death and uses a representative large cohort of type 1 diabetic patients who have a large amount of clinical data and national registers.

In a population cohort study of 5460 Danish adults who were clinically diagnosed with type 1 diabetes from 2001 to 2016, researchers developed an ESKD prediction model to explain the risk of competitive death.

The results of the study showed that during a median follow-up of 10.

In this study, researchers have deduced and verified an efficient model based on the predictors collected routinely in clinical practice to predict the individual risk of ESKD in adults with type 1 diabetes.

In the deduction (A) and validation (C) cohorts, follow up the C statistics of ESKD events for several years, and in the deduction (B) and validation (D) cohorts to test the P value of the model fit properly.

The cumulative incidence of ESKD in the Danish derivation and verification cohort was twice that of the Scottish verification cohort, which was much higher than previously reported in Sweden and Finland.

In short, this new, high-performance ESKD prediction model can be used for risk stratification of adult type 1 diabetes population.

Reference: A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes Dorte Vistisen, Gregers S.
Andersen, Adam Hulman, Stuart J.
McGurnaghan, Helen M.
Colhoun, Jan E.
Henriksen, Reimar W.
Thomsen, Frederik Persson , Peter Rossing, Marit E.
Jørgensen Diabetes Care Apr 2021, 44 (4) 901-907; diabetesjournals.
org/content/44/4/901.
full-text.
pdf" target="_blank" rel="noopener">DOI: 10.
2337/dc20-2586 Reference: A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes Dorte Vistisen, Gregers S .
Andersen, Adam Hulman, Stuart J.
McGurnaghan, Helen M.
Colhoun, Jan E.
Henriksen, Reimar W.
Thomsen, Frederik Persson, Peter Rossing, Marit E.
Jørgensen Diabetes Care Apr 2021, 44 (4) 901-907; diabetesjournals.
org/content/44/4/901.
full-text.
pdf" target="_blank" rel="noopener">DOI : 10.
2337/dc20-2586Reference: A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes Dorte Vistisen, Gregers S.
Andersen, Adam Hulman, Stuart J.
McGurnaghan, Helen M.
Colhoun, Jan E.
Henriksen, Reimar W.
Thomsen, Frederik Persson , Peter Rossing, Marit E.
Jørgensen Diabetes Care Apr 2021, 44 (4) 901-907; diabetesjournals.
org/content/44/4/901.
full-text.
pdf" target="_blank" rel="noopener">DOI: 10.
2337/dc20-2586 Reference: A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes Dorte Vistisen, Gregers S .
Andersen, Adam Hulman, Stuart J.
McGurnaghan, Helen M.
Colhoun, Jan E.
Henriksen, Reimar W.
Thomsen, Frederik Persson, Peter Rossing, Marit E.
Jørgensen Diabetes Care Apr 2021, 44 (4) 901-907; diabetesjournals.
org/content/44/4/901.
full-text.
pdf" target="_blank" rel="noopener">DOI : 10.
2337/dc20-2586Reference: A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes Dorte Vistisen, Gregers S.
Andersen, Adam Hulman, Stuart J.
McGurnaghan, Helen M.
Colhoun, Jan E.
Henriksen, Reimar W.
Thomsen, Frederik Persson , Peter the Rossing, Marit E.
Jørgensen on Apr 2021 Diabetes Care, 44 is (.
4) 901-907; diabetesjournals.
org/content/44/4/901.
full-text.
pdf" target="_blank" rel="noopener">the DOI: 10.
2337 / dc20-2586diabetesjournals.
org/content/44/4/901.
full-text.
pdf" target="_blank" rel="noopener"> the DOI: 10.
2337 / dc20-2586 in this message

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