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Purpose: With the increase of insulin secretion rate (ISR), endogenous insulin clearance (EIC) decreases physiologically
.
Calculating the EIC of the current ISR cannot distinguish the effects of hypersecretion from other glucose homeostasis mechanisms
As insulin secretion rate (ISR) increases, endogenous insulin clearance (EIC) decreases physiologically
Results: Insulin sensitivity (M/I as an orthoglycemic clamp) is the strongest determinant of EIC, and its influence is about 4 times that of insulin resistance-related hypersecretion
.
EIC was independently positively correlated with M/I, fasting and average OGTT blood glucose or type 2 diabetes, β-cell glucose sensitivity, and negatively correlated with African American or Hispanic, female gender and female age
Figure 1 The time course of insulin (AJ group) and C peptide (KN group) concentration (black) and the prediction of the mathematical model of insulin kinetics (grey), mean ±SE
.
Each figure represents a study, as shown in the panel title
Figure 1 The time course of insulin (AJ group) and C peptide (KN group) concentration (black) and the prediction of the mathematical model of insulin kinetics (grey), mean ±SE
Figure 2 Estimates the individual steady-state relationship between liver insulin concentration (x-axis) and liver clearance (y-axis)
.
Each graph represents a specific study, and each curve represents a specific individual
Figure 2 Estimates the individual steady-state relationship between liver insulin concentration (x-axis) and liver clearance (y-axis)
Figure 3 Standardization coefficients of non-stepwise multivariate linear analysis of EIC100, EIC400 and EICred in EUCLAMP, HGCLAMP/EUCLAMP and 2EUCLAMP studies
.
The coefficients of categorical variables are not standardized
Figure 3 Standardization coefficients of non-stepwise multivariate linear analysis of EIC100, EIC400 and EICred in EUCLAMP, HGCLAMP/EUCLAMP and 2EUCLAMP studies
Based on EIC, we hypothesize that there are two adaptive processes related to insulin clearance: the first process reduces EIC through insulin resistance (BMI itself is not high) and is more related to high secretion; the second reduces EIC with β cell function Obstacles
Bizzotto R, Tricò D, Natali A,et al.
New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms in this message
