Diabetes: Circulatory metabolites and lipids associated with diabetic retinal lesions in people with type 1 diabetes.

A histological-based approach may provide new markers for the diagnosis of diabetic retinal lesions (DR).
, researchers looked at the histological spectrum of metabolites and lipids associated with DR in people with type 1 diabetes, according to a recent study published in Diabetes, an authoritative journal in the field of diabetes.
researchers analyzed the two-dimensional gas chromatography of flight time mass spectrometrometrometromety in samples from 648 patients with type 1 diabetes, and liposomal histology using the super-efficient liquid chromatography four-flight time mass spectrometrometromety.
the researchers classified subjects as non-DR, mild non-multiplies DR (NPDR), moderate NPDR, multiplifying DR, and fibrosis-rich DR.
the end of the study was any progression in DR, DR seizures, and mild to severe DR progression tracked from standard outpatient care, and was studied using the Cox model.
the queue consisted of 648 participants, with an average age of 54.4 to 12.8 years, 55.5 per cent for men and 5.1-5.5 years for follow-up.
in cross-sectional studies, 2,4-dihydroxybutyric acid (DHBA), 3,4-DHBA, nucleic acid, ucose alcohol, 50:1 and 50:2 triglycerides were significantly associated with DR progress .
in longitudinal studies, a higher 3,4-DHBA is a hazard marker for adjusted DR progression (n=133) (P=0.033).
, the study proves that multiple metabolites are positively associated with DR in people with type 1 diabetes.
addition, the higher 3,4-DHBA is an independent risk indicator of DR progress.
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