Diabetes Obes Metab: Efficacy and safety of oral saxagliptin in the treatment of type 2 diabetes in Japan

Background and purpose: Saxagliptin is a once-daily oral tablet containing glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA), and absorption enhancer N-( 8-[2-Hydroxybenzoyl]amino)caprylic acid sodium is co-prepared to facilitate oral administration
.

Oral saxagliptin is approved in Japan, Europe and the United States for the treatment of poorly controlled adult type 2 diabetes (T2D)

GLP-1RAs are usually recommended in combination with other hypoglycemic drugs (usually including metformin)

Results: After oral administration of 7 mg and 14 mg saxagliptin, the glycosylated hemoglobin of Japanese patients decreased by 1.
0% to 1.
2% (11.
3 mmol/mol to 13.
3 mmol/mol) and 1.
4% to 1.
7% (15.
7 mmol/mol to 15.
7 mmol/mol).
18.
3 mmol/mol)
.

The reduction of glycosylated hemoglobin is similar to or greater than that of the comparative country

Table 1 Treatment (A) and baseline characteristics (B) of Japanese patients in PIONEER 1, 3, 4, and 8

Table 1 Treatment (A) and baseline characteristics (B) of Japanese patients in PIONEER 1, 3, 4, and 8

Figure 1 The baseline changes of HbA1c in Japanese patients with PIONEER1, 3, 4, and 8
.

Data from the observation period in the trial is included in the statistical analysis

Figure 1 The baseline changes of HbA1c in Japanese patients with PIONEER1, 3, 4, and 8

Figure 2 Changes in body weight (%) of Japanese patients in PIONEER 1, 3, 4, and 8 from baseline
.

Data from the observation period in the trial is included in the statistical analysis

Figure 2 Changes in body weight (%) of Japanese patients in PIONEER 1, 3, 4, and 8 from baseline

Table 2 Adverse events (AEs) (A) and the most common gastrointestinal AEs (B) during treatment of Japanese patients with PIONEER 1, 3, 4 and 8

Table 2 Adverse events (AEs) (A) and the most common gastrointestinal AEs (B) during treatment of Japanese patients with PIONEER 1, 3, 4 and 8

Conclusion: Oral saxagliptin is effective and well tolerated in Japanese patients with type 2 diabetes
.

Oral saxagliptin is effective and well tolerated in Japanese patients with type 2 diabetes
.

Original source:

Araki E, Terauchi Y, Watada H,et al.

Efficacy and safety of oral semaglutide in Japanese patients with type 2 diabetes: A post-hoc subgroup analysis of the PIONEER 1, 3, 4 and 8 trials.
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