Diabetogia: High-circulating proteins associated with increased risk of primary cardiovascular events in diabeticpatients

In experimental and cross-sectional studies, high concentrations of fatty proteins were associated with lower levels of risk factors for heart metabolism, but in population-based cohort studies, the risk of type 2 diabetes and cardiovascular disease was higherHowever, it is not clear whether high protein concentrations are associated with an increased risk of cardiovascular events in diabetic patientsTherefore, this study explores the relationship between serum wave protein concentration and cardiovascular event risk in diabetic patientsthis prospective study is based on the inclusion of a history of cardiovascular events in patients with diabetes in Esteline, GermanyThe ESTHER queue is made up of individuals aged 50-75 and is recruited by a general practitionerExcluding individuals with serum c-reactive proteins of 10 mg/l (?95.24 nmol/l), the final analysis population was 933At the baseline, the serum protein concentration is measured using the ELISA methodFit the Cox regression model to estimate the complex endpoint of the mesh tripeptide syd, the correlation with myocardial infarction, stroke, and cardiovascular death, and its corresponding 95% CIstudy showed that 228 people experienced primary cardiovascular events (myocardial infarction, stroke, or cardiovascular death) over a 14-year follow-up periodAfter combining age, gender, BMI, metabolic and lifestyle factors and medication, HRs (95% CI) in the second and third triesidos were 1.24 (95% CI), respectively, compared to the 1st tri-digit1.79) and 1.63 (1.15, 2.32) (P trend s 0.005); 2.99(P trend s 0.065); stroke is 1.40 (0.78, 2.53) and 2.05 (1.17, 3.58) (ptrend s 0.010); Cardiovascular deaths were 1.43 (0.85, 2.40) and 1.72 (1.04, 2.83) respectively (ptren - 0.040)After further correction of lipolicosin, the effect estimate and p value remain almost constantafter correcting a variety of cardiovascular risk factors, higher wave protein concentrations were associated with an increased risk of cardiovascular events in diabetic patientsAccording to preclinical studies, this link may reflect a compensatory, but an increase in the concentration of retinal proteins is not sufficient as a response to the increased cardiovascular risk