Diabetogia: Maternal obesity affects future generations?
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Last Update: 2020-06-25
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Source: Internet
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Author: User
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Obesity during pregnancy increases the risk of type 2 diabetes in future generationsGiven that nearly half of women of childbearing age are currently overweight/obese, it is important to raise awareness of the impact of the intrauterine/early living environment on islet function in future generationsWhile numerous experimental studies have examined the effects of maternal obesity on islet structure and/or function in future generations, it is not clear whether these changes are independent of other mixed risk factors, such as obesity, postnatal hyperlipidelate and agingTherefore, the purpose of this study is to study the effects of maternal obesity on the islet seweated of male and female offspringglucose tolerance is similar regardless of the mother's diet and the sex of the offspringHowever, in obese female offspring after 15 minutes of glucose, blood sugar was lower (p 0.001) and plasma insulin was higher (p 0.05)This is associated with higher glucose (p 0.01) and leucine/glutamine-stimulated (p 0.05) insulin secretion in these offspringIn addition, mitochondrial breathing (p 0.01) and density (p 0.05) increased for obese female offspring compared to same-sex controlgender differences in islet function of maternal obesity childrenThe islets of female offspring rather than male offspring appear to be in response to a nutrient-rich postnatal environment, which may reflect differences in the risk of future type 2 diabetes
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