Diabetogia: The relationship between plasma beta-amyloid 40 and 42 in Chinese adults is associated with type 2 diabetes.

There is !---- evidence of a two-way link between type 2 diabetes and Alzheimer's diseaseplasma beta-amyloid protein (A-beta) is a potential biomarker of Alzheimer's diseasewe aim to study the relationship between plasma Beta 40 and A beta 42 and the risk of type 2 diabetesWe conducted case-control studies and nested case control studies in prospective cohort studiesIn the case control study, we included 1,063 newly diagnosed type 2 diabetes patients and 1,063 participants in the control group who were age-matching and gender-matchingin nested case control studies, we included 121 patients with type 2 diabetes and 242 patients with controlelectrochemical luminescent immunoassay measures simultaneously determine the concentrations of plasma A beta 40 and A beta 42conditional regression is used to assess the relationship between plasma A beta 40 and A beta 42 concentrations and the likelihood of type 2 diabetesin case-control studies, the multivariate adjusted OR for type 2 diabetes was 1.97 (95% CI 1.46, 2.66) and 2.01 (95% CI 1.50), 2.69, respectively, compared with the highest and lowest quartiles of plasma A beta concentrationsthe chance of a 30 ng / l and type 2 diabetes increased by 28% (95% CI 15%, 43%), and plasma A beta 42 increased by 21% and 55% for every increase in 5 ng / l and 37% (95% CI) of type 2 diabetesthe highest triple-digit populations of plasma A beta 40 and A beta 42 were 2.96 times more likely to develop type 2 diabetes than those with the lowest triple digits of plasma A beta 40 and A beta 42in the nest case control study, the multivariate correction of type 2 diabetes with plasma A beta 40 and the lowest quart of four digits was 3.79 (95% CI 1.81, 7.94) and 2.88 (95% CI 1.44, 5.75) of plasma A beta 40, respectivelymultivariate correction ORs for each increase of 30 ng / l and plasma A beta 42 for each increase of 5 ng / l related to type 2 diabetes were 1.44 (95% CI 1.18, 1.74) and 1.47 (95% CI 1.15, 1.88), respectivelyour findings indicate a positive correlation between plasma A beta 40 and A beta 42 concentrations associated with the risk of type 2 diabetestherefore, further research is needed to clarify its underlying mechanisms and to explore the potential role of plasma A beta in linking type 2 diabetes to Alzheimer's disease.