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Early onset of type 2 diabetes in adults (diagnosed between the ages of 18 and 39) is becoming more common and has been shown to be associated with poor long-term prognosis.
hypothesical that early-oncercation adults with type 2 diabetes were not adequately represented in important study trials of type 2 diabetes management guidelines.
researchers reviewed the average age of the population in 90 major trials of type 2 diabetes, including 37 cardio-renal prognosis trials involving a range of pharmacological, non-pharmacological and multifaceted interventions, and 28 trials from three Phase III programs representing blood sugar - regular use of antihypertensive therapies (Iglisin, liraglutide and statins) and 25 important exercise-supervised exercise trials involving diabetes self-management education and intensive lifestyle interventions (diet or intensive lifestyle interventions).
then estimated the number of individuals between the ages of 18 and 39 in the trials.
study showed that in all 90 trials, the average age of 268,978 participants was 63 years (the age range for individual trials was 51-69 years).
in 73 trials (81%), less than 5% of participants were estimated to be 18-39 years old, representing 15-20% of adults with type 2 diabetes.
29 of these trials (32 per cent; a total of 164,953 participants) excluded persons under the age of 40.
guidelines for early onset of type 2 diabetes in adults are based primarily on evidence from older adults.
strategies must be adopted to support the participation of early-onset adults with type 2 diabetes in future studies to ensure that guidelines for these high-risk groups are evidence-based.
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