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Diabetologia: Gender differences in organ fat levels and liver lipid metabolism: Effects of dietary weight loss on cardiovascular health and remission of type 2 diabetes

 Last Update: 2021-12-03
 Source: Internet
 Author: User

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The development of type 2 diabetes leads to a disproportionate increase in the risk of cardiovascular disease in women, approaching that of men

Female high subcutaneous fat (SAT) will lead to excess of body fat stores, which may be caused by the different liver fat metabolism lead to the increase of liver triglyceride VLDL1- excessive fat accumulation in the liver (VLDL1-TG) of Output and plasma VLDL1-TG concentration

Methods: The subjects of the study were type 2 diabetes group (n=64, male 30/34 female) and healthy person group (n=25, male 13/12 female)

Participants and study design: This study is part of DiRECT (n=64, 30 males/34 females; age 52.

Participants and study design:

Quantification of VLDL1-TG: This is done using a non-isotopic method [5]

Quantification of VLDL1-TG:

Magnetic resonance study: Magnetic resonance (MR) data was collected using a 3.

Magnetic resonance research:

Diabetes in remission: This is defined as HbA1c<6

Diabetes remission period:

Biochemical and cardiovascular disease risk analysis: Standard methods are used to determine triacylglycerol, insulin, glucose and other blood metabolites

Biochemical and cardiovascular disease risk analysis:

Results: The levels of triacylglycerol in the liver and pancreas of diabetic patients were elevated without gender difference (female liver 16.

Table of clinical and metabolic characteristics of men and women before and after weight loss

Figure Changes in blood lipid variables after weight loss in women and men

In patients with type 2 diabetes, women’s liver and pancreatic fat levels are as high as men’s, which is related to increased liver VLDL1-TG production

Jesuthasan A, Zhyzhneuskaya S, Peters C,et al.

Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss.

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