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In recent decades, the prevalence of cardiometabolic diseases such as obesity, metabolic syndrome and diabetes among Chinese residents has risen rapidly, threatening the health of residents .
Metabolic Syndrome Diabetes Vascular Healthy Life>Effective Way to Prevent and Control These Diseases A Healthy Life>Effective Way to Prevent and Control Such Diseases
In recent years, the rapid development of metabolomics technologies, including lipidome, has provided an opportunity for the discovery of early biomarkers of disease, and the interpretation of metabolic pathways and regulatory factors related to the occurrence and development of diseases
However, relevant prospective cohort studies are limited, especially in Asian populations
The study included 1877 Chinese community residents (751 men and 1126 women) aged 50-70 years without diabetes at baseline and followed for 6 years
During the 6-year follow-up, 499 participants (26.
After multivariate adjustment, 8 GPLs were positively associated with developing diabetes (RRper SD 1.
It was also associated with unhealthy dietary patterns high in refined grains and low in fish, dairy and soy products (|factor load| ≥ 0.
When stratified by level of physical activity, the associations of the eight GPLs and PC modules with onset diabetes were stronger in participants with lower levels of physical activity than in participants with intermediate and higher levels of physical activity
When stratified by level of physical activity, the associations of the eight GPLs and PC modules with onset diabetes were stronger in participants with lower levels of physical activity than in participants with intermediate and higher levels of physical activity
In conclusion, in the Chinese population, 8 GPLs, especially the PC related to the DNL pathway, were positively correlated with the occurrence of diabetes
references:
Associations of plasma glycerophospholipid profile with modifiable life> Diabetologia 65, 315–328 (2022).
Associations of plasma glycerophospholipid profile with modifiable life>
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