Diabetologia: The likelihood of progression score identifies substations of pre-symptomatic type 1 diabetes in childhood public health screening

Background: In patients with advanced (stage 2) symptoms of pre-type 1 diabetes, immunotherapy can delay the onset

As demonstrated by the Fr1da Institute, islet autoantibody screening based on the pediatric population is possible

Objective: The aim of this study was to develop a strategy to identify children with advanced symptoms of pre-type 1 diabetes from the general population and therefore potentially benefit

Methods: We tested children aged 1.

Results: Among the 447 children with multiple islet autoantibodies, 364 children were staged (81.

Figure 1 Progression

Figure 2 A multivariate analysis

Figure 3 Children with type 1 diabetes progress to type 1 diabetes mellitus, stratified based on the likelihood of progression score, to type 3 diabetes

Figure 4 Children with type 2 or type 1 diabetes progress to type 3 and type 1 diabetes, stratified by likelihood of progression

Conclusion: Public health screening of islet autoantibodies found that 0.

Original source: Weiss A, Zapardiel-Gonzalo J, Voss F, et al.