Diabetologia: The relationship between pre-diabetes status and mortality, diabetes-related complications and comorbidities

Purpose: Pre-diabetes (IDF) refers to the population whose glucose metabolism is impaired and the level of blood sugar or glycosylated hemoglobin is not high enough to be diagnosed as diabetes
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This definition is met if at least one of the following criteria is met: impaired fasting blood glucose (IFG) (fasting blood glucose 5.

Pre-diabetes (IDF) refers to people whose glucose metabolism is impaired, and the level of blood sugar or glycosylated hemoglobin is not high enough to be diagnosed as diabetes

Results: 95 Meta analyses were screened out of 16 documents
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In the general population, the incidence of pre-diabetes and all-cause mortality and cardiovascular disease, coronary heart disease, stroke, heart failure, atrial fibrillation and chronic kidney disease increased by 6%-101%, as well as liver cancer, hepatocellular carcinoma, and breast cancer Related to the incidence of all-cause dementia, the evidence has certain certainty

Table 1 Definition of pre-diabetes

Table 1 Definition of pre-diabetes

Figure 1 Flow chart of the research selection process

Figure 1 Flow chart of the research selection process

Table 2 The relationship between pre-diabetes and diabetes-related complications, comorbidities and mortality in the general population
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a The explanation of the certainty of evidence is represented by a crossed circle: four symbols, high; three symbols, medium; two symbols, low; one symbol, very low

Table 2 The relationship between pre-diabetes and diabetes-related complications, comorbidities and mortality in the general population

Table 3 The relationship between pre-diabetes and cardiovascular disease risk, cardiovascular mortality, and total mortality in patients with previous diseases.
The certainty of the interpretation evidence is represented by a crossed circle: four symbols, high; three symbols, medium; two Symbol, low; one symbol, very low
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b Patients with atherosclerotic cardiovascular disease

Table 3 The relationship between pre-diabetes and cardiovascular disease risk, cardiovascular mortality, and total mortality in patients with previous diseases.

Pre-diabetes is positively correlated with the incidence of all-cause mortality, cardiovascular disease, coronary heart disease, stroke, chronic kidney disease, cancer, and dementia

Schlesinger S, Neuenschwander M, Barbaresko J, et al.

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Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies.
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