Diabetologia: Using a hybrid closed-loop system to study the dietary determinants of postprandial glycemic control in adults with type 1 diabetes

Patients with type 1 diabetes, especially postprandial blood glucose control is a challenge
.

Carbohydrates (CHOs) are the main determinant of the postprandial glucose response (PGR)

Carbohydrates (CHOs) are the main determinant of the postprandial glucose response (PGR)

Results: Breakfast, lunch and dinner had significant differences in energy, nutrient intake and insulin dosage
.

The postprandial blood glucose curve showed an earlier peak after breakfast, and did not rise slowly until 4 hours after lunch and dinner (p<0.

Figure 1 Blood glucose concentration (solid line, meaning ±SE) and insulin dose are automatically used by the pump as post-meal microboluses and adjusted pills are recommended by participants according to hcl (vertical bar) breakfast (n = 398) (a), lunch (n = 4 4 1) (b) and dinner (n = 4 2 5) (c)

Figure 1 Blood glucose concentration (solid line, meaning ±SE) and insulin dose are automatically used by the pump as post-meal microboluses and adjusted pills are recommended by participants according to hcl (vertical bar) breakfast (n = 398) (a), lunch (n = 4 4 1) (b) and dinner (n = 4 2 5) (c)

Figure 2 CGM has indicators for breakfast, lunch and dinner
.

Means ±SD; *p<0.

Figure 2 CGM has indicators for breakfast, lunch and dinner

Table 1 The relationship between dietary nutrients and blood sugar control (TIR 3.
9-10.
0 mmol/l) at breakfast, lunch and dinner

Table 1 The relationship between dietary nutrients and blood sugar control (TIR 3.
9-10.
0 mmol/l) at breakfast, lunch and dinner

Table 2 In the early postprandial period (0-3 hours) and 3-6 hours, the nutritional content and insulin dose after the meal (pill automatically provided by the pump plus the adjustment pill provided by the participant according to the HCLS recommendation) relation

Table 2 In the early postprandial period (0-3 hours) and 3-6 hours, the nutritional content and insulin dose after the meal (pill automatically provided by the pump plus the adjustment pill provided by the participant according to the HCLS recommendation) relation

Conclusion: This study shows that nutritional factors other than the amount of carbohydrates significantly affect postprandial blood glucose control
.

These nutritional determinants are different between breakfast, lunch and dinner, and have different effects on blood glucose levels and insulin requirements after meals, so HCLS is still a challenge

This study shows that nutritional factors other than the amount of carbohydrates significantly affect postprandial blood glucose control

Vetrani C, Calabrese I, Cavagnuolo L, et al.

Dietary determinants of postprandial blood glucose control in adults with type 1 diabetes on a hybrid closed-loop system.
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