Diabetologia: What was the time trend for the diagnosis of type 1 diabetes in children with diabetic ketoacidosis between 2006 and 2016?

This study conducted an international retrospective study of DKA for diabetes diagnosis.
aims to assess the geographic variation and trends in the incidence of type 1 diabetes (DKA) in children in 13 countries on three continents between 2006 and 2016.
Data from DKA (age, sex, date of diagnosis of diabetes, ethnic minority status) from Australia, Austria, Czech Republic, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, United States and United Kingdom (Wales).
the average prevalence for the entire period, including overall and country-by-country, and corrected by gender and age group.
using a logistic regression analysis method to estimate the time trend of DKA annual prevalence in each country before and after the adjustment of gender, age group and ethnic minority status.
during the study period, 59,000 children were diagnosed with new type 1 diabetes (median age (quarter-digit range), 9.0 years (5.5-11.7); male, 52.9%).
DKA prevalence was 29.9 per cent, with Sweden and Denmark with the lowest prevalence and Luxembourg and Italy with the highest.
, Germany and the United States, adjusted DKA prevalence increased significantly over time, while in Italy it declined.
most countries, preschool children, adolescents and children from ethnic minorities are most at risk of developing DKA in diabetes diagnosis.
women in Denmark, Germany and Slovenia were also significantly at higher risk.
prevalence of type 1 diabetes diagnoses varies widely from country to country, is generally high, and increased slightly between 2006 and 2016.
suggest that it is necessary to raise awareness of symptoms to prevent delays in diagnosis, especially for pre-school children, adolescents and children from ethnic minorities.
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