Dig Dis Sci: Late-stage liver fibrosis in patients with chronic hepatitis B is associated with necrotizing inflammation and is not associated with liver fat degeneration

Chronic hepatitis B (CHB) is a global health problem affecting about 250 million people worldwide, and people with CHB can have adverse consequences such as liver failure, cirrhosis and hepatocellular carcinoma (HCC).
reported that the elderly, male, HBeAg-positive, elevated levels of alanine transaminase (ALT), highly active replication of HBV DNA, while infection with other hepatitis viruses and higher levels of quantitative HBsAg are risk factors for liver disease progression.
the prevalence of hepatitis B in patients with hepatitis B increased from 14% to 76%.
reported higher levels of histological cirrhosis in CHB patients with metabolic syndrome (MetS) and closely related to NAFLD (38% vs. 11%, p .lt;0.001).
study aims to investigate the association between HS and liver fibrosis and to explore predictive factors for late fibrosis.
the researchers reviewed clinical data on patients who received liver biopsies and were fully evaluated for HS, necrotizing inflammation grades (HISI) scores, and fibrosis phased CHBs.
all patients performed a logical regression analysis to determine the factors associated with advanced liver fibrosis.
of the 672 patients, 342 (50.9%) had HS and 267 (39.4%) had advanced liver fibrosis.
age (OR) 1.026,95% confidence interval (CI) 1.007-1.046, p s 0.008), body mass index (BMI, OR 1 .091,95% CI 1.026-1.159, p - 0.005), genotype (C vs B) (OR 2.790, 95% CI 1.84 7-4.214, p-lt;0.001), plateplates (OR 0.986, 95% CI 0.982-0.991, p-lt;0.0 01) and HAI score (OR 1.197, 95% CI 1.114-1.285, p -lt;0.001) are independent factors of late liver fibrosis in multi-factor Logistic regression analysis.
HAI score is also a significant correlation for severe liver fibrosis in non-cirrhosis substations (OR 1.578,95% CI 1.375-1.810, p .lt;0.001).
in the population with general/non-hepatic cirrhosis, HS was not associated with late/significant liver fibrosis (p.
study found that clinical and pathological characteristics had an effect on liver fibrosis in CHB patients.
HS may only be a potential metS liver manifestation, independent of the severity of liver fibrosis.
hai represents necrotizing inflammation as an independent predictor of late or severe liver fibrosis.