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Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by repeated alternating disease recurrence and remission.
UC mainly affects the shallow layer of the colon mucous membrane, and lesions such as mucosal edema, erythema, ulcers and so on can be observed in active UC patients.
of mucous membrane healing (MH) was inversely inversely related to the rate of clinical recurrence, hospitalization and surgery, and colorectal cancer.
MH is therefore a therapeutic target for IBD.
serum globulin is a hallmark of inflammation, which increases the production of a variety of globulins, including immunoglobulins and acute stage proteins, leading to high globulinemia.
so far, there is no evidence of a link between serum globulin and disease activity in patients with ulcerative colitis.
study was designed to assess the relationship between serum globulin and endoscopic activity in patients with ulcerative colitis.
The patients were divided into three groups (low globulin group, ≤2.7 g / dl (reference);
endoscope expert evaluated the results of the endoscope examination and evaluated mucous membrane healing based on the Mayo endoscope score.
the study included 277 patients with ulcerative colitis.
positive correlation between globulin and intestinal ulcers was found in the globulin (OR 2.00 (95% CI: 1.05-3.86).
serum globulin independently showed a negative correlation with mucosal healing (moderate: OR 0.37 (95% CI: 0.18-0.73) and high: corrected OR 0.31 (95% CI:0.14-0.64), trend p s 0.001.
negative correlation between globulin and mucosal healing was evident in the low-C-reactive proteome, but not in the high-C-reactive proteome.
This study found a significant positive correlation between serum globulin and endoscopic activity in patients with ulcerative colitis, and significantly negative correlation with mucosal healing, especially in patients with low C-reactive proteins.
