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Click the blue text above to follow us A new study of 104 children finds that disruption of the lung microbiome may explain why some children with blood cancers and other blood diseases tend to have lower survival rates after stem cell transplants
.
This analysis answers a long-standing question in the field of stem cell transplantation
.
This suggests that finding these microbiome signatures may allow scientists to predict and prevent adverse transplant outcomes through closer monitoring and improved treatment
.
More than 7,500 children in the United States and Europe receive stem cell transplants each year to treat leukemia, bone marrow failure syndrome and other blood-related diseases
.
However, as many as 40 percent of these children will develop severe lung damage after transplantation, putting them at a higher risk of death
.
To find out, Matt Zinter and colleagues performed lung function and bronchoalveolar lavage fluid tests on 104 Dutch children with leukemia or other blood disorders who were scheduled to receive stem cell transplantation
.
More than half of these patients showed signs of poor lung function before transplantation, which the researchers linked to a higher risk of death after surgery
.
In addition, children with poor lung function displayed a disrupted lung microbiota (eg, loss of commensal Haemophilus) and more active expression of genes involved in fibrosis and alveolar epithelial cell activation
.
By incorporating tests of these microbes and changes in their gene expression, Zinter et al.
found that they could predict mortality after stem cell transplantation better than testing lung function alone
.
The team cautioned that further research is needed to determine the causal relationship between the lung microbiome and transplant outcomes and its mechanism of action
.
Welcome to pay attention to the official official account of Science.
Click "Read the original text" below to visit the original English page.
If you like this content, click "Like".
.
This analysis answers a long-standing question in the field of stem cell transplantation
.
This suggests that finding these microbiome signatures may allow scientists to predict and prevent adverse transplant outcomes through closer monitoring and improved treatment
.
More than 7,500 children in the United States and Europe receive stem cell transplants each year to treat leukemia, bone marrow failure syndrome and other blood-related diseases
.
However, as many as 40 percent of these children will develop severe lung damage after transplantation, putting them at a higher risk of death
.
To find out, Matt Zinter and colleagues performed lung function and bronchoalveolar lavage fluid tests on 104 Dutch children with leukemia or other blood disorders who were scheduled to receive stem cell transplantation
.
More than half of these patients showed signs of poor lung function before transplantation, which the researchers linked to a higher risk of death after surgery
.
In addition, children with poor lung function displayed a disrupted lung microbiota (eg, loss of commensal Haemophilus) and more active expression of genes involved in fibrosis and alveolar epithelial cell activation
.
By incorporating tests of these microbes and changes in their gene expression, Zinter et al.
found that they could predict mortality after stem cell transplantation better than testing lung function alone
.
The team cautioned that further research is needed to determine the causal relationship between the lung microbiome and transplant outcomes and its mechanism of action
.
Welcome to pay attention to the official official account of Science.
Click "Read the original text" below to visit the original English page.
If you like this content, click "Like".
