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Vitamin D prevents breast cancer stem cells 1.
NAC and GSH promote tumor formation and growth in liver cancer mouse models and xenogeneic liver cancer models.
Immune 2.
NAC and GSH exhibit a cancer-promoting effect on human liver cancer cells in vitro, and desensitize NRF2/GCLC related Antioxidant production pathway 3, NAC and GSH can promote the growth and progression of human HCC cells in the body, accompanied by the attenuation of intracellular ROS levels.
4 Antioxidants NAC and GSH promote tumor formation of human HCC cells in vivo 5, NAC and GSH can up-regulate the expression of liver cancer stem cell markers and stem cell genes6 , NAC and GSH in vitro and in vivo counteract the tumor suppressive effect of sorafenib in human HCC cells Molecular targeting7 , NAC and GSH change the influence on metabolism and expression Common molecular pathway of genetics 8.
TMBIM1 is up-regulated after NAC and GSH treatment.
Knockdown of TMBIM1 can neutralize the carcinogenic effects caused by antioxidants in vitro.
9.
Targeting inhibitors of GSH and NAC metabolism can eliminate the promotion of NAC and GSH.
Cancer effect
org/10.
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NAC and GSH promote tumor formation and growth in liver cancer mouse models and xenogeneic liver cancer models.
Immune 2.
NAC and GSH exhibit a cancer-promoting effect on human liver cancer cells in vitro, and desensitize NRF2/GCLC related Antioxidant production pathway 3, NAC and GSH can promote the growth and progression of human HCC cells in the body, accompanied by the attenuation of intracellular ROS levels.
4 Antioxidants NAC and GSH promote tumor formation of human HCC cells in vivo 5, NAC and GSH can up-regulate the expression of liver cancer stem cell markers and stem cell genes6 , NAC and GSH in vitro and in vivo counteract the tumor suppressive effect of sorafenib in human HCC cells Molecular targeting7 , NAC and GSH change the influence on metabolism and expression Common molecular pathway of genetics 8.
TMBIM1 is up-regulated after NAC and GSH treatment.
Knockdown of TMBIM1 can neutralize the carcinogenic effects caused by antioxidants in vitro.
9.
Targeting inhibitors of GSH and NAC metabolism can eliminate the promotion of NAC and GSH.
Cancer effect
Original source:
Zhang et al.
Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM.
Cell & Bioscience (2021) 11:217
https://doi.
org/10.
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