DOM: Comparison of methods of transition from insulin pump to multiple injections of insulin degludec

Using insulin glargine U100 or insulin detemir to convert from an insulin pump to MDI requires a 1:1 dose conversion; that is, calculate the total daily basal rate of the insulin pump, and use the same dose of insulin glargine every day while stopping the insulin pump U100 or insulin detemir
.
Insulin degludec (IDeg) is a generation of long-acting insulin analogues

Materials and methods: After a one-week run-in period, patients with type 1 diabetes who have used an insulin pump for at least 6 months (with a duration of more than one year and HbA1c of 48-69 mmol/mol (6.
5%-8.
5%), random transfer It is the standard of care (stopping the insulin pump, starting IDeg at a 1:1 dose) or overlapping use (IDeg at the base dose of the pump is 1:1, but the pump lasts for the first 48 hours, with a gradual reduction in the base; 0-24 hours is 50%, 24 -48 hours for 75%, then stop the pump)
.
Participants used blinded Dexcom G6, and the IDeg dose did not change during the trial

Results: The age, gender, duration of diabetes, and basal/additional insulin doses were similar among patients randomly assigned to the standard of care (n=17) or overlap insulin (n=13) transition
.
The standard care group spent 4.

Table 1 Baseline characteristics of participants (n=30)

Table 2 Primary and major secondary blood glucose outcomes (n=30)

Conclusion: In the first week of adult patients with type 1 diabetes from the insulin pump to the use of IDeg's MDI, the overlap conversion method can significantly improve within the time frame without increasing hypoglycemia
.

Original source:

Shah VN, Akturk HK, Joseph H, et al, A randomized controlled trial of transition from insulin pump to multiple daily injections using insulin degludec.