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PARPs (Poly(ADP-ribose) polymerase) is a superfamily of proteins responsible for transferring ADP-ribose groups to target proteins and modifying target proteins by ADP ribosylation (ADPr).
They are widely involved in DNA damage repair.
Transcription regulation, chromosomal protein remodeling and other important biological processes
.
Recent studies have shown that PARPs not only play an irreplaceable role in maintaining genome stability and regulating signal pathways, but also play an important role in regulating the body's natural immune response
.
Recently, Dr.
Zhu Huifang from the First Affiliated Hospital of Gannan Medical College published a review in Frontiers in Immunology: The Critical Role of PARPs in Regulating Innate ImmuneResponses, which systematically reviewed the latest research progress in related fields and summarized the role of PARPs in regulating tumors, viral infections, and inflammation.
And the molecular mechanisms in the natural immune response related to cellular emergency stress
.
Full text link: https://pubmed.
ncbi.
nlm.
nih.
gov/34367175/Frontiers inImmunology (Frontiers in Immunology) is a peer-reviewed open access journal and the official journal of the International Union of Immunological Societies (IUIS) , The latest impact factor of 7.
6 in 2020
.
The journal aims to publish the most outstanding research results covering the entire field of immunology
.
In addition to the research papers on the basic mechanisms of the development and function of the immune system, it also emphasizes the description of the clinical and immunophenotypes of human immune diseases, as well as the definition of their molecular basis
.
First author: Zhu Huifang, Ph.
D.
(Bachelor of Shenyang Pharmaceutical University, Master of Wuhan Institute of Virology, Chinese Academy of Sciences, Ph.
D of Kunming Institute of Botany, Chinese Academy of Sciences), First Affiliated Hospital of Gannan Medical College, Children's Medical Center, Department of Neonatology, Lecturer; concurrently served as Gannan Medical College , School of Basic Medical Sciences, master's tutor
.
The main research directions include the exploration of the molecular mechanism of antiviral natural immunity and the immunotherapy of childhood leukemia tumors
.
Corresponding author: Professor Chunfu Zheng served as editor of mBio (zero breakthrough of Chinese local editors), editorial board member of Journal of Virology (one of the first two selected local editors in China); also served as Frontiers in Microbiology, Virology Journal, Journal of Medical Virology Associate editor and guest editor of Frontiers in Immunology
.
Professor Zheng Chunfu has made breakthrough research results in the study of the molecular mechanism of the interaction between herpes simplex virus type I (HSV-1) infection and the host, and the study of HSV-1 escape host antiviral natural immunity.
He has made breakthrough research results in Trends in Microbiology (IF 17.
079), Microbiology and Molecular Biology Reviews (cover article, IF 12.
568), FEMS MicrobiologyReviews (IF 16.
408), Blood (IF 22.
169), CellHost & Microbe (IF 21.
023), Proceedings of the National Academy of Sciences USA (IF 11.
205), Protein and Cell (IF 14.
870 ; 2 articles), mBio (IF 7.
867), Cytokine& Growth Factor Reviews (IF 7.
658), Journal of Virology (23 articles, 2 of which are highlight articles; IF 5.
103), Journal of Immunology (2 articles, IF 5.
422) and other mainstream The journal has published more than 100 SCI papers, with a total number of citations of more than 2,300, and an H-index of 28
.
Laboratory website: https://bms.
fjmu.
edu.
cn/2017/1130/c2905a72170/page.
htm The call for papers on the Frontiers in Microbiology subject by Professor Chunfu Zheng is still in progress, and the current deadline is October 31
.
15 articles have been published and 5 articles are under review
.
https:// 2020 hot articles selection 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
They are widely involved in DNA damage repair.
Transcription regulation, chromosomal protein remodeling and other important biological processes
.
Recent studies have shown that PARPs not only play an irreplaceable role in maintaining genome stability and regulating signal pathways, but also play an important role in regulating the body's natural immune response
.
Recently, Dr.
Zhu Huifang from the First Affiliated Hospital of Gannan Medical College published a review in Frontiers in Immunology: The Critical Role of PARPs in Regulating Innate ImmuneResponses, which systematically reviewed the latest research progress in related fields and summarized the role of PARPs in regulating tumors, viral infections, and inflammation.
And the molecular mechanisms in the natural immune response related to cellular emergency stress
.
Full text link: https://pubmed.
ncbi.
nlm.
nih.
gov/34367175/Frontiers inImmunology (Frontiers in Immunology) is a peer-reviewed open access journal and the official journal of the International Union of Immunological Societies (IUIS) , The latest impact factor of 7.
6 in 2020
.
The journal aims to publish the most outstanding research results covering the entire field of immunology
.
In addition to the research papers on the basic mechanisms of the development and function of the immune system, it also emphasizes the description of the clinical and immunophenotypes of human immune diseases, as well as the definition of their molecular basis
.
First author: Zhu Huifang, Ph.
D.
(Bachelor of Shenyang Pharmaceutical University, Master of Wuhan Institute of Virology, Chinese Academy of Sciences, Ph.
D of Kunming Institute of Botany, Chinese Academy of Sciences), First Affiliated Hospital of Gannan Medical College, Children's Medical Center, Department of Neonatology, Lecturer; concurrently served as Gannan Medical College , School of Basic Medical Sciences, master's tutor
.
The main research directions include the exploration of the molecular mechanism of antiviral natural immunity and the immunotherapy of childhood leukemia tumors
.
Corresponding author: Professor Chunfu Zheng served as editor of mBio (zero breakthrough of Chinese local editors), editorial board member of Journal of Virology (one of the first two selected local editors in China); also served as Frontiers in Microbiology, Virology Journal, Journal of Medical Virology Associate editor and guest editor of Frontiers in Immunology
.
Professor Zheng Chunfu has made breakthrough research results in the study of the molecular mechanism of the interaction between herpes simplex virus type I (HSV-1) infection and the host, and the study of HSV-1 escape host antiviral natural immunity.
He has made breakthrough research results in Trends in Microbiology (IF 17.
079), Microbiology and Molecular Biology Reviews (cover article, IF 12.
568), FEMS MicrobiologyReviews (IF 16.
408), Blood (IF 22.
169), CellHost & Microbe (IF 21.
023), Proceedings of the National Academy of Sciences USA (IF 11.
205), Protein and Cell (IF 14.
870 ; 2 articles), mBio (IF 7.
867), Cytokine& Growth Factor Reviews (IF 7.
658), Journal of Virology (23 articles, 2 of which are highlight articles; IF 5.
103), Journal of Immunology (2 articles, IF 5.
422) and other mainstream The journal has published more than 100 SCI papers, with a total number of citations of more than 2,300, and an H-index of 28
.
Laboratory website: https://bms.
fjmu.
edu.
cn/2017/1130/c2905a72170/page.
htm The call for papers on the Frontiers in Microbiology subject by Professor Chunfu Zheng is still in progress, and the current deadline is October 31
.
15 articles have been published and 5 articles are under review
.
https:// 2020 hot articles selection 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
